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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .EPW | U.S. Department of Energy | Data Files | EnergyPlus Weather Data File | EnergyPlus | U.S. Department of Energy |
| .EPZ | EON Reality | Data Files | EON Studio Personal Edition File | EON Studio | EON Reality |
| .EQD | Cattlesoft, Inc. | Data Files | EquineMax Data File | EquineMax | Cattlesoft, Inc. |
| .EQW | Petr Skoda | Data Files | SPEFO Stellar Spectra Analysis File | SPEFO | Astronomical Institute of the Czech Academyof Sciences |
| .ER1 | CA Technologies | Data Files | ERWin Entity Relationship Diagram | ERwin | CA Technologies |
| .ER2 | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERD | Open Source | Data Files | Entity Relation Diagram | DBeaver | Open Source |
| .ERE | EagleEyeOS LLC. | Data Files | EagleEyeOS Report File | EagleEyeOS | Eagle Eye Digital Solutions (EEDS) |
| .ERG | RacerMate Inc. | Data Files | CompuTrainer Workout File | CompuTrainer | RacerMate Inc. |
| .ERI | XnSoft | Data Files | ERI-chan (Entis Rasterized Image) Image Format | XnView MP | XnSoft |
| .ERIC | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERP | Future Games | Data Files | Alter Ego Game Archive | Alter Ego | Future Games |
| .ERWIN | CA Technologies | Data Files | ERwin Data Modeler Model | ERwin | CA Technologies |
| .ES | Interscape | Data Files | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESB | Season Workshop | Data Files | Es-Builder Book File | Season Workshop es-Builder | Season Workshop |
| .ESJ | Thermwood Corporation | Data Files | eCabinet CAD File | eCabinet Systems | Thermwood Corporation |
| .ESK | Interactive Data Corporation | Data Files | eSignal Scan File | eSignal | Interactive Data Corporation |
| .ESO | Design Builder | Data Files | DesignBuilder EnergyPlus Output File | DesignBuilder | Design Builder |
| .ESP | Bethesda Softworks | Data Files | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESR | 4D, Inc | Data Files | 4D Database External Data | 4D | 4D, Inc |
| .ESS | Bethesda Softworks | Data Files | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .EST | Microsoft Corporation | Data Files | Streets & Trips Map File | Microsoft MapPoint | Microsoft Corporation |
| .ESX | Xactware Solutions | Data Files | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .ET | RM Education | Data Files | Easiteach Lesson File | Research Machines Easiteach | RM Education |
| .ET1 | Unknown Developer | Data Files | Energy 10 Weather Data | Energy 10 | Open Source |
| .ET3 | Microsec Software Engineering & Consulting Plc. | Data Files | E-Szigno Recorded Delivery Data | e-Szigno | Microsec Software Engineering & Consulting Plc. |
| .ETB | Project Pluto | Data Files | Project Pluto Guide Event Table | Project Pluto Guide | Project Pluto |
| .ETBP | Textbook Solutions Limited | Data Files | eTextbookCreator Project File | eTextbookCreator | Textbook Solutions Limited |
| .ETH | Qualis Research Associates | Data Files | Ethnograph Document | Qualis Research Associates Ethnograph | Qualis Research Associates |
| .ETP | Microsoft Corporation | Data Files | Visual Studio Enterprise Template Project | Microsoft Visual Studio | Microsoft Corporation |
| .ETS | Enthuware | Data Files | Enthuware Test Studio Document | Enthuware Test Studio | Enthuware |
| .ETT | Kingsoft | Data Files | Kingsoft Spreadsheets Template | WPS Office | Kingsoft |
| .EUHL | Qualcomm | Data Files | Eudora For Mac Help File | QUALCOMM Eudora | Qualcomm |
| .EUK | Moziak Digital Learning | Data Files | Euklides Dynamic Geometry | Euklides | Moziak Digital Learning |
| .EUP | Jerome Lamy | Data Files | EagleUp Data | EagleUp | Jerome Lamy |
| .EUX | Intelligent Software | Data Files | Eulogica Funeral Information | Eulogica | Intelligent Software |
| .EV | Echoview Software Pty Ltd | Data Files | Echoview File | Echoview | Echoview Software Pty Ltd |
| .EV3 | The LEGO Group | Data Files | LEGO MINDSTORMS EV3 Project | LEGO MINDSTORMS EV3 | The LEGO Group |
| .EVC | DeskSoft | Data Files | Earthview Data File | Earthview | DeskSoft |
| .EVE | Open Source | Data Files | Embedded Vector Editor Diagram | Embedded Vector Editor | Open Source |
| .EVI | Echoview Software Pty Ltd | Data Files | Echoview Index File | Echoview | Echoview Software Pty Ltd |
| .EVL | Echoview Software Pty Ltd | Data Files | EchoView Exported Line File | Echoview | Echoview Software Pty Ltd |
| .EVY | Corel | Data Files | Corel Envoy Document | Corel WordPerfect | Corel |
| .EWF | Open Source | Data Files | Trollzsoft EpicWriter File | EpicWriter | Open Source |
| .EWG | Dassault Systèmes | Data Files | SolidWorks File Format | SOLIDWORKS | Dassault Systèmes |
| .EWS | Softouch Development, Inc | Data Files | EasyWorship Schedule File | EasyWorship | Softouch Development, Inc |
| .EX2 | Unknown Developer | Data Files | Exodus II File | Exodus II | Unknown Developer |
| .EX4 | MetaQuotes Software Corp | Data Files | MetaTrader Program Format | MetaQuotes MetaTrader | MetaQuotes Software Corp |
| .EXB | CAXA | Data Files | CAXA Draft | IronCAD | IronCAD, LLC |
| .EXC | Lionhead Studios | Data Files | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXE2 | Unknown Developer | Data Files | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .EXEMPLE | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EXF | Open Source | Data Files | Exchangeable Image File Format | Photo Studio | Open Source |
| .EXI | exida.com | Data Files | ExSILentia Project | exSILentia | exida.com |
| .EXL | SysTools Solutions | Data Files | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXM | Boson Holdings | Data Files | Boson Exam File | Boson Exam Environment | Boson Holdings |
| .EXP | Unknown Developer | Data Files | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXPLOSION | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EYE | EyeMail Technology Inc. | Data Files | Eyemail Video Recording File | ETI Monet TV | EyeMail Technology Inc. |
| .EZD | Julio Gómez Herrero & José María Gómez Rodríguez | Data Files | WSxM Image Data | WSxM | Julio Gómez Herrero & José María Gómez Rodríguez |
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