| .EPW | U.S. Department of Energy | Arquivos de dados | EnergyPlus Weather Data File | EnergyPlus | U.S. Department of Energy |
| .EPZ | EON Reality | Arquivos de dados | EON Studio Personal Edition File | EON Studio | EON Reality |
| .EQD | Cattlesoft, Inc. | Arquivos de dados | EquineMax Data File | EquineMax | Cattlesoft, Inc. |
| .EQW | Petr Skoda | Arquivos de dados | SPEFO Stellar Spectra Analysis File | SPEFO | Astronomical Institute of the Czech Academyof Sciences |
| .ER1 | CA Technologies | Arquivos de dados | ERWin Entity Relationship Diagram | ERwin | CA Technologies |
| .ER2 | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERD | Open Source | Arquivos de dados | Entity Relation Diagram | DBeaver | Open Source |
| .ERE | EagleEyeOS LLC. | Arquivos de dados | EagleEyeOS Report File | EagleEyeOS | Eagle Eye Digital Solutions (EEDS) |
| .ERG | RacerMate Inc. | Arquivos de dados | CompuTrainer Workout File | CompuTrainer | RacerMate Inc. |
| .ERI | XnSoft | Arquivos de dados | ERI-chan (Entis Rasterized Image) Image Format | XnView MP | XnSoft |
| .ERIC | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .ERP | Future Games | Arquivos de dados | Alter Ego Game Archive | Alter Ego | Future Games |
| .ERWIN | CA Technologies | Arquivos de dados | ERwin Data Modeler Model | ERwin | CA Technologies |
| .ES | Interscape | Arquivos de dados | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESB | Season Workshop | Arquivos de dados | Es-Builder Book File | Season Workshop es-Builder | Season Workshop |
| .ESJ | Thermwood Corporation | Arquivos de dados | eCabinet CAD File | eCabinet Systems | Thermwood Corporation |
| .ESK | Interactive Data Corporation | Arquivos de dados | eSignal Scan File | eSignal | Interactive Data Corporation |
| .ESO | Design Builder | Arquivos de dados | DesignBuilder EnergyPlus Output File | DesignBuilder | Design Builder |
| .ESP | Bethesda Softworks | Arquivos de dados | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESR | 4D, Inc | Arquivos de dados | 4D Database External Data | 4D | 4D, Inc |
| .ESS | Bethesda Softworks | Arquivos de dados | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .EST | Microsoft Corporation | Arquivos de dados | Streets & Trips Map File | Microsoft MapPoint | Microsoft Corporation |
| .ESX | Xactware Solutions | Arquivos de dados | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .ET | RM Education | Arquivos de dados | Easiteach Lesson File | Research Machines Easiteach | RM Education |
| .ET1 | Unknown Developer | Arquivos de dados | Energy 10 Weather Data | Energy 10 | Open Source |
| .ET3 | Microsec Software Engineering & Consulting Plc. | Arquivos de dados | E-Szigno Recorded Delivery Data | e-Szigno | Microsec Software Engineering & Consulting Plc. |
| .ETB | Project Pluto | Arquivos de dados | Project Pluto Guide Event Table | Project Pluto Guide | Project Pluto |
| .ETBP | Textbook Solutions Limited | Arquivos de dados | eTextbookCreator Project File | eTextbookCreator | Textbook Solutions Limited |
| .ETH | Qualis Research Associates | Arquivos de dados | Ethnograph Document | Qualis Research Associates Ethnograph | Qualis Research Associates |
| .ETP | Microsoft Corporation | Arquivos de dados | Visual Studio Enterprise Template Project | Microsoft Visual Studio | Microsoft Corporation |
| .ETS | Enthuware | Arquivos de dados | Enthuware Test Studio Document | Enthuware Test Studio | Enthuware |
| .ETT | Kingsoft | Arquivos de dados | Kingsoft Spreadsheets Template | WPS Office | Kingsoft |
| .EUHL | Qualcomm | Arquivos de dados | Eudora For Mac Help File | QUALCOMM Eudora | Qualcomm |
| .EUK | Moziak Digital Learning | Arquivos de dados | Euklides Dynamic Geometry | Euklides | Moziak Digital Learning |
| .EUP | Jerome Lamy | Arquivos de dados | EagleUp Data | EagleUp | Jerome Lamy |
| .EUX | Intelligent Software | Arquivos de dados | Eulogica Funeral Information | Eulogica | Intelligent Software |
| .EV | Echoview Software Pty Ltd | Arquivos de dados | Echoview File | Echoview | Echoview Software Pty Ltd |
| .EV3 | The LEGO Group | Arquivos de dados | LEGO MINDSTORMS EV3 Project | LEGO MINDSTORMS EV3 | The LEGO Group |
| .EVC | DeskSoft | Arquivos de dados | Earthview Data File | Earthview | DeskSoft |
| .EVE | Open Source | Arquivos de dados | Embedded Vector Editor Diagram | Embedded Vector Editor | Open Source |
| .EVI | Echoview Software Pty Ltd | Arquivos de dados | Echoview Index File | Echoview | Echoview Software Pty Ltd |
| .EVL | Echoview Software Pty Ltd | Arquivos de dados | EchoView Exported Line File | Echoview | Echoview Software Pty Ltd |
| .EVY | Corel | Arquivos de dados | Corel Envoy Document | Corel WordPerfect | Corel |
| .EWF | Open Source | Arquivos de dados | Trollzsoft EpicWriter File | EpicWriter | Open Source |
| .EWG | Dassault Systèmes | Arquivos de dados | SolidWorks File Format | SOLIDWORKS | Dassault Systèmes |
| .EWS | Softouch Development, Inc | Arquivos de dados | EasyWorship Schedule File | EasyWorship | Softouch Development, Inc |
| .EX2 | Unknown Developer | Arquivos de dados | Exodus II File | Exodus II | Unknown Developer |
| .EX4 | MetaQuotes Software Corp | Arquivos de dados | MetaTrader Program Format | MetaQuotes MetaTrader | MetaQuotes Software Corp |
| .EXB | CAXA | Arquivos de dados | CAXA Draft | IronCAD | IronCAD, LLC |
| .EXC | Lionhead Studios | Arquivos de dados | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXE2 | Unknown Developer | Arquivos de dados | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .EXEMPLE | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EXF | Open Source | Arquivos de dados | Exchangeable Image File Format | Photo Studio | Open Source |
| .EXI | exida.com | Arquivos de dados | ExSILentia Project | exSILentia | exida.com |
| .EXL | SysTools Solutions | Arquivos de dados | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXM | Boson Holdings | Arquivos de dados | Boson Exam File | Boson Exam Environment | Boson Holdings |
| .EXP | Unknown Developer | Arquivos de dados | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXPLOSION | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EYE | EyeMail Technology Inc. | Arquivos de dados | Eyemail Video Recording File | ETI Monet TV | EyeMail Technology Inc. |
| .EZD | Julio Gómez Herrero & José María Gómez Rodríguez | Arquivos de dados | WSxM Image Data | WSxM | Julio Gómez Herrero & José María Gómez Rodríguez |
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