| .SA4 | DeLorme | GIS filer | Delorme Street Atlas USA File | DeLorme Street Atlas USA | DeLorme |
| .SA7 | DeLorme | GIS filer | Street Atlas 7 Map Document | DeLorme Street Atlas USA | DeLorme |
| .SA8 | DeLorme | GIS filer | Street Atlas 8 Map Document | DeLorme Street Atlas USA | DeLorme |
| .SAF | DeLorme | GIS filer | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SBN | ESRI | GIS filer | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SBP | Autodesk, Inc. | GIS filer | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SDC | Stardock Corporation | GIS filer | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDF | Microsoft Corporation | GIS filer | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | GIS filer | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDM | Oracle Corporation | GIS filer | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDW | LizardTech | GIS filer | MrSID World File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHP | Autodesk, Inc. | GIS filer | AutoCAD Shape File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
| .SLD | ESRI (Environmental Systems Research Institute) | GIS filer | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SMM | Samsung Electronics | GIS filer | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SMP | MakeMusic, Inc. | GIS filer | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SOS | 3AM Solutions | GIS filer | Dynamite VSP Swept Object Style File | Dynamite VSP | 3AM Solutions |
| .SSF | Unknown Developer | GIS filer | Structured Subtitle Format File | Microsoft Notepad | Microsoft Corporation |
| .STN | ON1, Inc. | GIS filer | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STT | Microsoft Corporation | GIS filer | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STYLE | Trimble Inc. | GIS filer | SketchUp Style | SketchUp | Trimble Inc. |
| .SVX | The Survex Project | GIS filer | Survex Cavern Data File | Microsoft Notepad | Microsoft Corporation |
| .SXD | ESRI | GIS filer | ArcScene Document | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SXF | KB Panorama | GIS filer | Storage And eXchange Format File | GIS Panorama | KB Panorama |
| .SYM | The Eclipse Foundation | GIS filer | Symbols File | Eclipse CDT | The Eclipse Foundation |
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