| .SA4 | DeLorme | GIS檔案 | Delorme Street Atlas USA File | DeLorme Street Atlas USA | DeLorme |
| .SA7 | DeLorme | GIS檔案 | Street Atlas 7 Map Document | DeLorme Street Atlas USA | DeLorme |
| .SA8 | DeLorme | GIS檔案 | Street Atlas 8 Map Document | DeLorme Street Atlas USA | DeLorme |
| .SAF | DeLorme | GIS檔案 | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SBN | ESRI | GIS檔案 | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SBP | Autodesk, Inc. | GIS檔案 | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SDC | Stardock Corporation | GIS檔案 | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDF | Microsoft Corporation | GIS檔案 | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | GIS檔案 | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDM | Oracle Corporation | GIS檔案 | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDW | LizardTech | GIS檔案 | MrSID World File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHP | Autodesk, Inc. | GIS檔案 | AutoCAD Shape File | Autodesk AutoCAD Ecscad | Autodesk, Inc. |
| .SLD | ESRI (Environmental Systems Research Institute) | GIS檔案 | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SMM | Samsung Electronics | GIS檔案 | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SMP | MakeMusic, Inc. | GIS檔案 | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SOS | 3AM Solutions | GIS檔案 | Dynamite VSP Swept Object Style File | Dynamite VSP | 3AM Solutions |
| .SSF | Unknown Developer | GIS檔案 | Structured Subtitle Format File | Microsoft Notepad | Microsoft Corporation |
| .STN | ON1, Inc. | GIS檔案 | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STT | Microsoft Corporation | GIS檔案 | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STYLE | Trimble Inc. | GIS檔案 | SketchUp Style | SketchUp | Trimble Inc. |
| .SVX | The Survex Project | GIS檔案 | Survex Cavern Data File | Microsoft Notepad | Microsoft Corporation |
| .SXD | ESRI | GIS檔案 | ArcScene Document | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SXF | KB Panorama | GIS檔案 | Storage And eXchange Format File | GIS Panorama | KB Panorama |
| .SYM | The Eclipse Foundation | GIS檔案 | Symbols File | Eclipse CDT | The Eclipse Foundation |
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