| .E2C | NJStar Software | Arquivos de dados | NJStar Chinese Word Processor Dictionary File Index | NJStar Chinese WP | NJStar Software |
| .E2P | Open Source | Arquivos de dados | PonyProg Device File | PonyProg | Open Source |
| .E32 | Jordan Russell | Arquivos de dados | Inno Setup 1.3 Data | Inno Setup | Open Source |
| .EAC | Emurasoft, Inc. | Arquivos de dados | EmEditor Auto-Completion Data | EmEditor | Emurasoft, Inc. |
| .EAP | Sparx Systems | Arquivos de dados | Enterprise Architect Project | Enterprise Architect | Sparx Systems |
| .EAS | Rockwell Automation Inc. | Arquivos de dados | RSLogix Symbol File | RSLogix 5 | Rockwell Automation Inc. |
| .EATF | Apple | Arquivos de dados | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .EAZ | ESRI (Environmental Systems Research Institute) | Arquivos de dados | ArcGIS Explorer Add-in File | Microsoft Visual Studio | Microsoft Corporation |
| .EBB | Metapraxis | Arquivos de dados | Empower Business Bulletin Data File | Empower | Metapraxis |
| .EBC | SourceForge | Arquivos de dados | MediaBASIC Compiled Project | MediaBASIC | SourceForge |
| .EBD | Microsoft Corporation | Arquivos de dados | Windows EBD System File | Microsoft Windows | Microsoft Corporation |
| .EBF | Microsoft Corporation | Arquivos de dados | Pocket PC WindowsCE Form | Microsoft Windows CE Embedded | Microsoft Corporation |
| .EBH | Robert Bentley, Inc. | Arquivos de dados | eBahn Desktop Automotive Repair Information Data File | eBahn Desktop | Robert Bentley, Inc. |
| .EBP | Jes-Soft | Arquivos de dados | Jes-Soft Sports Play Description | Jes-Soft Playbook | Jes-Soft |
| .EBUILD | Gentoo Foundation, Inc. | Arquivos de dados | Portage eBuild Script | Gentoo Portage | Gentoo Foundation, Inc. |
| .EBV | ASH WARE | Arquivos de dados | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Arquivos de dados | Rational Rose 98 Compiled Script | Rational Rose | IBM |
| .EC3 | Epson US | Arquivos de dados | EPSON Print CD File | EPSON Print CD | Epson US |
| .ECC | Carsten Gnörlich | Arquivos de dados | Dvdisaster Error Correction File | dvdisaster | Carsten Gnörlich |
| .ECF | Microsoft Corporation | Arquivos de dados | Outlook Add-in | Microsoft Outlook | Microsoft Corporation |
| .ECG | Open Source | Arquivos de dados | Electrocardiography Data | FreeECG | Open Source |
| .ECH | SourceForge | Arquivos de dados | EasyChem Saved Data | EasyChem | SourceForge |
| .ECL | Team Shanghai Alice | Arquivos de dados | Touhou Stage Script | Touhou ToolKit | Touhou Patch Center |
| .ECP | Intelitek | Arquivos de dados | EasyC Project File | EasyC | Intelitek |
| .ECT | Yozosoft | Arquivos de dados | Yozo Office Chart Template File | Yozosoft Yozo Office | Yozosoft |
| .EDD | Adobe Systems Incorporated | Arquivos de dados | Adobe FrameMaker Element Definition Document File | Adobe FrameMaker | Adobe Systems Incorporated |
| .EDF | ESRF | Arquivos de dados | ESRF Data File | SAXS Program Package | ESRF |
| .EDG | Pacestar Software | Arquivos de dados | Edge Diagrammer File | Pacestar Edge Diagrammer | Pacestar Software |
| .EDH | MindWare Technologies | Arquivos de dados | HRV Edit Data | Heart Rate Variability (HRV) Analysis Software | MindWare Technologies |
| .EDI | Unknown Developer | Arquivos de dados | Electronic Data Interchange File | Microsoft Excel | Microsoft Corporation |
| .EDP | National Instruments | Arquivos de dados | NI Multisim Data | NI Multisim | National Instruments |
| .EDPI | PrestoSoft LLC | Arquivos de dados | ExamDiff Pro Session File | ExamDiff Pro | PrestoSoft LLC |
| .EDT | Adobe Systems Incorporated | Arquivos de dados | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EEG | Compumedics Neuroscan | Arquivos de dados | EEG Data File | Neuroscan Curry | Compumedics Neuroscan |
| .EEP | Open Source | Arquivos de dados | EEPROM Data File | HHD Hex Editor | HHD Software |
| .EER | Lahey Computer Systems, Inc. | Arquivos de dados | Lahey Fortran Error Data | Lahey Fortran | Lahey Computer Systems, Inc. |
| .EF | Blackboard Collaborate | Arquivos de dados | Diploma Exam File | Wimba Diploma | Blackboard Collaborate |
| .EFC | Unknown Developer | Arquivos de dados | EFCoins File | Unknown Software | Unknown Developer |
| .EFP | Microsoft Corporation | Arquivos de dados | Exchange Forms Designer Template | Microsoft Exchange Server | Microsoft Corporation |
| .EFS | ESRI | Arquivos de dados | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EFT | Cay Horstmann | Arquivos de dados | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EFX | j2 Global, Inc. | Arquivos de dados | eFax Document | j2 Global Communications eFax | j2 Global, Inc. |
| .EGB | Encog Machine Learning Framework | Arquivos de dados | Encog Binary Data | Encog Machine Learning Framework | Encog Machine Learning Framework |
| .EGF | CSC - IT Center for Science | Arquivos de dados | Elmer Front Geometry Definition Data | Elmer Front | CSC - IT Center for Science |
| .EGP | Edline | Arquivos de dados | Easy Grade Pro Gradebook File | Edline Easy Grade Pro | Edline |
| .EGR | Crestron Electronics | Arquivos de dados | Crestron Studio Engraver Document File | Crestron Studio | Crestron Electronics |
| .EGT | EagleGet | Arquivos de dados | EagleGet Temporary File | EagleGet | EagleGet |
| .EGV | Canon Inc. | Arquivos de dados | Canon Easy Guide Viewer File | Canon Easy Guide Viewer | Canon Inc. |
| .EIA | Excellon Automation | Arquivos de dados | Excellon Data | Microsoft Notepad | Microsoft Corporation |
| .EID | IBM | Arquivos de dados | IBM Voice Type Languages Newuser File | IBM Voice Type | IBM |
| .EIF | Envex Solutions | Arquivos de dados | Envex Import Format File | xFlow | Envex Solutions |
| .EIO | Yozosoft | Arquivos de dados | Yozo Office File | Yozosoft Yozo Office | Yozosoft |
| .EIS | Synthesoft, Inc. | Arquivos de dados | EIS Spectrum Analyser Project | CD/Spectrum Pro | Synthesoft, Inc. |
| .EKA | Borland | Arquivos de dados | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKB | ZMC | Arquivos de dados | ZMC Visual Tablet Data | ZMC VisualTablet for AutoCAD | ZMC |
| .EKR | EEG Store | Arquivos de dados | EEGer Data | EEGer | EEG Store |
| .EKS | Metapraxis | Arquivos de dados | Metapraxis Empower Data File | Empower | Metapraxis |
| .EL | GNU Project | Arquivos de dados | Emacs Lisp Code File | GNU Emacs | GNU Project |
| .EL2 | Canon Inc. | Arquivos de dados | Easy-PhotoPrint EX Sticker File | Easy-PhotoPrint EX | Canon Inc. |
| .EL3 | Canon Inc. | Arquivos de dados | Canon Easy-PhotoPrint EX File | Easy-PhotoPrint EX | Canon Inc. |
| .ELC | GNU Project | Arquivos de dados | Emacs Compiled Lisp File | GNU Emacs | GNU Project |
| .ELD | DIAL | Arquivos de dados | Eulumdat Formatted Luminaire Data File | DIAL DIALux | DIAL |
| .ELG | Energy Scitech Limited | Arquivos de dados | Enable Activity Log | ENABLE Software | Energy Scitech Limited |
| .ELI | Novarm | Arquivos de dados | DipTrace Data | DipTrace | Novarm |
| .ELL | Advanced Micro Devices, Inc. | Arquivos de dados | AMD ATI Radeon Video Driver | ATI Multimedia Center | Advanced Micro Devices, Inc. |
| .ELN | Blackboard Collaborate | Arquivos de dados | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .ELOG | McAfee, Inc. | Arquivos de dados | McAffee Firewall Log File | McAfee Internet Security | McAfee, Inc. |
| .ELP | Open Source | Arquivos de dados | eXe Learning Package File | eXeLearning | Open Source |
| .ELS | TradeStation | Arquivos de dados | EasyLanguage Storage File | EasyLanguage | TradeStation |
| .ELSEWHERE | Unknown Developer | Arquivos de dados | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .ELT | NEPLAN AG | Arquivos de dados | NEPLAN Topology Data | NEPLAN Electricity | NEPLAN AG |
| .EMAT | ANSYS, Inc. | Arquivos de dados | ANSYS Element Matrix File | ANSYS DesignModeler | ANSYS, Inc. |
| .EMB | Everest Software | Arquivos de dados | Everest Embedded Bank File | Awave Studio | FMJ-Software |
| .EMBL | European Molecular Biology Laboratory (EMBL) | Arquivos de dados | EMBL Sequence Data File | DNASTAR Lasergene | DNASTAR |
| .EMD | FMJ-Software | Arquivos de dados | ABT Extended Module File | Awave Studio | FMJ-Software |
| .EMP | Open Source | Arquivos de dados | eMusic Music Download File | eMusic/J | Open Source |
| .EMS | Intergraph Corporation | Arquivos de dados | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .ENB | Open Source | Arquivos de dados | eNotebook Notebook File | eNotebook | Open Source |
| .ENC | Smith Micro Software | Arquivos de dados | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | Arquivos de dados | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENE | KTH Royal Institute of Technology | Arquivos de dados | GROMACS Binary Energy File | Gromacs | KTH Royal Institute of Technology |
| .ENG | Unknown Developer | Arquivos de dados | Chess Engine | ChessMaster | Ubisoft Blue Byte |
| .ENH | Open Source | Arquivos de dados | CRiSP Harvest Model Enhancement File | CRiSP Harvest | Open Source |
| .ENL | Thomson Reuters Corporation | Arquivos de dados | EndNote Library | EndNote | Thomson Reuters Corporation |
| .ENM | e-undertown | Arquivos de dados | Enewsletter Manager Message File | eNewletter Manager | e-undertown |
| .ENS | Thomson Reuters Corporation | Arquivos de dados | EndNote Style File | EndNote | Thomson Reuters Corporation |
| .ENV | Adobe Systems Incorporated | Arquivos de dados | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .ENX | IBM | Arquivos de dados | IBM Rational XDE Data | Rational XDE | IBM |
| .EON | EON Reality | Arquivos de dados | EON Studio File | EON Studio | EON Reality |
| .EOP | Everyone Piano Inc. | Arquivos de dados | EveryonePiano Music Score File | Everyone Piano | Everyone Piano Inc. |
| .EOT | Microsoft Corporation | Arquivos de dados | Embedded OpenType Font | Web Embedding Fonts Tool (WEFT) | Microsoft Corporation |
| .EOX | EON Reality | Arquivos de dados | EON Studio Project | EON Studio | EON Reality |
| .EOZ | EON Reality | Arquivos de dados | EON Studio File | EON Studio | EON Reality |
| .EPB | WebWorks | Arquivos de dados | ePublisher File | ePublisher | WebWorks |
| .EPC | Sumo Digital Ltd. | Arquivos de dados | Doctor Who Game Data File | BBC Doctor Who: The Adventure Games | Sumo Digital Ltd. |
| .EPF | Vero Software | Arquivos de dados | Edgecam Educational Part File | Planit Edgecam | Vero Software |
| .EPJ | Grass Valley | Arquivos de dados | EDIUS Pro Project File | Thomson EDIUS | Grass Valley |
| .EPL | Open Source | Arquivos de dados | Tallyman E-commerce Software File | TallyMan | Open Source |
| .EPP | Talasoft | Arquivos de dados | TalaPhoto Project | TalaPhoto | Talasoft |
| .EPT | Adobe Systems Incorporated | Arquivos de dados | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
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