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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .SAS7BDAT | SAS Institute Inc. | Database Files | SAS Data Set File | SAS | SAS Institute Inc. |
| .SBF | Database Files | Android System File | Google Android | ||
| .SCX | RIX SoftWorks, Inc. | Database Files | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SD2 | Avid Technology | Database Files | Sound Designer II File | Apple iTunes | Apple |
| .SDF | Microsoft Corporation | Database Files | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | Database Files | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDS | Oracle Corporation | Database Files | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SF1 | The U.S. Census Bureau | Database Files | 2010 Census Summary File 1 | Microsoft Access | Microsoft Corporation |
| .SG3 | SourceForge | Database Files | ChessDB Game File | ChessDB | Interscape |
| .SIS | Valve | Database Files | Steam Game Backup Information File | Steam | Valve |
| .SKC | Borland | Database Files | SideKick For Windows Database File | Borland SideKick | Borland |
| .SLF | Symantec Corporation | Database Files | Symantec License File | Symantec Ghost Solution Suite | Symantec Corporation |
| .SQDB | TedCo Software, LLC | Database Files | SpellQuizzer Database File | SpellQuizzer | TedCo Software, LLC |
| .SQL | Various Developers | Database Files | Structured Query Language Data File | Microsoft Notepad | Microsoft Corporation |
| .SQLITE | Dwayne Richard Hipp | Database Files | SQLite Database File | SQLite | Dwayne Richard Hipp |
| .SQLITEDB | Dwayne Richard Hipp | Database Files | SQLite Database | SQLite | Dwayne Richard Hipp |
| .SR1 | SIR Pty Ltd. | Database Files | SIR Database | SIR/XS | SIR Pty Ltd. |
| .SR3 | SIR Pty Ltd. | Database Files | SIR Database | SIR/XS | SIR Pty Ltd. |
| .SR4 | SIR Pty Ltd. | Database Files | SIR Database | SIR/XS | SIR Pty Ltd. |
| .SSO | Interscape | Database Files | ChessDB Search Options Data | ChessDB | Interscape |
| .SV2 | SAS Institute Inc. | Database Files | SAS View | Base SAS | SAS Institute Inc. |
| .SV7 | Nintendo | Database Files | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
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