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| Extension | File Type Developer | File Category | File Type Description | Software | Software Developer |
|---|---|---|---|---|---|
| .S7Z | Igor Pavlov | Compressed Files | 7-Zip Compressed File | ZDevs ZArchiver | Interscape |
| .SAV | Nintendo | Game Files | Saved Game File | Dualis | Interscape |
| .SBC | Microsoft Corporation | Uncommon Files | Office Accounting Company Shortcut File | SBC File Archiver | Interscape |
| .SC2 | EA Maxis | Game Files | SimCity 2000 City File | Sample Cell II | Interscape |
| .SCAR | Interscape | Executable Files | SCAR Script File | SCAR | Interscape |
| .SCW | Genie | Uncommon Files | Score Writer Document | Screenwriter's Print Script Viewer | Interscape |
| .SERVER | Interscape | Data Files | Bonobo Activation API File | GNOME Desktop | Interscape |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Audio Files | IRCAM Sound File | RMCProfile | Interscape |
| .SFW | Seattle Lab | Raster Image Files | Seattle FilmWorks Image | American Greetings SFW & PWP File Converter | Interscape |
| .SG3 | SourceForge | Database Files | ChessDB Game File | ChessDB | Interscape |
| .SGA | Relic Entertainment | Game Files | Relic Entertainment Game Archive | Mod Studio 2 | Interscape |
| .SHX | Autodesk, Inc. | CAD Files | AutoCAD Compiled Shape File | RSD Lite | Interscape |
| .SI3 | Interscape | Data Files | ChessDB Index File | ChessDB | Interscape |
| .SMF | Oracle Corporation | Text Files | StarMath Formula File | Appspeed SkinMagic Toolkit | Interscape |
| .SN3 | Samsung Electronics | Backup Files | Samsung Kies 2 Backup | ChessDB | Interscape |
| .SNL | Interscape | Data Files | Egrid32 Form Snippet | EGrid Form Designer | Interscape |
| .SOU | LucasArts Entertainment Company, LLC | Game Files | Lucas Arts Sound Data | ScummVM | Interscape |
| .SPF | StorageCraft | Backup Files | ShadowProtect Full Backup File | SlingPlayer | Interscape |
| .SPM | Corel | Data Files | Corel WordPerfect Data | StoneTracker | Interscape |
| .SPS | IBM | Data Files | SPSS Program File | StoneTracker | Interscape |
| .SRO | Unknown Developer | Data Files | MADCOW Multi-Site ATIS Data Collection Working Group Data | MADCOW (Multi-Site ATIS Data Collection Working Group) | Interscape |
| .SRT | SourceForge | Video Files | SubRip Subtitle File | Aegisub | Interscape |
| .SSA | Open Source | Text Files | Sub Station Alpha Subtitle File | J2 Interactive MX Player | Interscape |
| .SSO | Interscape | Database Files | ChessDB Search Options Data | ChessDB | Interscape |
| .STM | Microsoft Corporation | Data Files | Exchange Streaming Media File | The Powder Toy | Interscape |
| .STR | dBase, LLC | Data Files | dBASE Structure List Object File | X-Plane | Interscape |
| .STY | Jørgen Sørensen / Jososoft | Audio Files | Yamaha/Korg Keyboard Style | GNIStyle | Interscape |
| .SUB | URUWORKS | Text Files | Subtitle File | J2 Interactive MX Player | Interscape |
| .SUC | Interscape | Data Files | Hello Engines! 2.1 Data | Hello Engines | Interscape |
| .SUD | Aivosto Oy | Developer Files | Super Project Analyzer Data File | WISCO Word Power | Interscape |
| .SV7 | Nintendo | Game Files | Saved Game File | Dualis | Interscape |
| .SVG | Nintendo | Game Files | Saved Game File | Dualis | Interscape |
| .SYN | Image-Line | Audio Files | SimSynth Document | Excessive Speed | Interscape |
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