| .DAE | Sony | File 3D | Digital Asset Exchange File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .DATA | Appricon | File di dati | Analysis Studio Offline Data | Adobe Soundbooth | Adobe Systems Incorporated |
| .DBF | dBase, LLC | File di database | Database File | JetForm FormFlow | Adobe Systems Incorporated |
| .DBM | Adobe Systems Incorporated | File web | ColdFusion Server File | Adobe ColdFusion Builder | Adobe Systems Incorporated |
| .DC2 | Kodak | File con immagini raster | Kodak Digital Camera RAW Image File | Adobe Photoshop | Adobe Systems Incorporated |
| .DCM | National Electrical Manufacturers Association (NEMA) | File con immagini raster | DICOM Image File Format | Adobe Photoshop | Adobe Systems Incorporated |
| .DCP | Embarcadero Technologies | File sviluppatore | Delphi Compiled Package | Adobe Photoshop CC | Adobe Systems Incorporated |
| .DCS | Quark Software Inc. | File con immagini vettoriali | Desktop Color Separation File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .DCX | ZSoft Corporation | File con immagini raster | Zsoft Multi-Page Paintbrush File | Adobe Photoshop | Adobe Systems Incorporated |
| .DDS | Microsoft Corporation | File con immagini raster | DirectDraw Surface | Adobe Photoshop | Adobe Systems Incorporated |
| .DEU | Adobe Systems Incorporated | File di dati | Adobe Reader German Language File | Adobe Reader | Adobe Systems Incorporated |
| .DFM | Open Source | File di testo | Pascal File | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .DHY | Adobe Systems Incorporated | File di dati | Adobe Bridge Information File | Adobe Bridge CC | Adobe Systems Incorporated |
| .DIB | The GIMP Development Team | File con immagini raster | Device Independent Bitmap File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .DIM | Active@ Data Recovery Software | File backup | Active@ Raw Disk Image Backup File | Adobe Dimensions | Adobe Systems Incorporated |
| .DIR | Adobe Systems Incorporated | File video | Adobe Director Movie | Adobe Director | Adobe Systems Incorporated |
| .DLG | Crytek | File di giochi | Crysis Dialogue Data File | ExtendScript Toolkit (ESTK) | Adobe Systems Incorporated |
| .DLM | AKAMAI | File vari | Akamai Download Manager File | Adobe Creative Cloud | Adobe Systems Incorporated |
| .DLV | Dassault Systèmes | File di CAD | CATIA 4 Export File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .DLX | DIAL | File di CAD | DIALux Document | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .DMV | Adobe Systems Incorporated | File di settaggi | Adobe Acrobat Catalog Data | Adobe Acrobat DC | Adobe Systems Incorporated |
| .DNG | Adobe Systems Incorporated | File Videocamera non elaborati | Digital Negative Image File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .DOG | Ubisoft Blue Byte | File di giochi | Dogz Dog Description File | Adobe Photoshop Elements | Adobe Systems Incorporated |
| .DPX | Kodak | File con immagini raster | Digital Picture Exchange File | Adobe SpeedGrade | Adobe Systems Incorporated |
| .DRT | Micrografx | File grafici | Micrografix Windows Draw Template File | Adobe Director | Adobe Systems Incorporated |
| .DRX | Adobe Systems Incorporated | File di dati | Adobe Photoshop Tutorial Data | Adobe Photoshop | Adobe Systems Incorporated |
| .DV | Roxio | File video | Digital Video File | Adobe Flash Professional CC | Adobe Systems Incorporated |
| .DWG | Autodesk, Inc. | File di CAD | AutoCAD Drawing Database File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .DWS | Autodesk, Inc. | File di CAD | AutoCAD Drawing Standards File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .DWT | Adobe Systems Incorporated | File web | Dreamweaver Web Page Template | Adobe Dreamweaver | Adobe Systems Incorporated |
| .DXF | Autodesk, Inc. | File di CAD | Drawing Exchange Format | Adobe Illustrator CC | Adobe Systems Incorporated |
| .DXR | Adobe Systems Incorporated | File video | Protected Macromedia Director Movie | Adobe Director | Adobe Systems Incorporated |
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