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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .SYL | Microsoft Corporation | Data Files | Symbolic Link Spreadsheet | Microsoft Excel | Microsoft Corporation |
| .SYLK | Microsoft Corporation | Data Files | Microsoft Symbolic Link File | Microsoft Excel | Microsoft Corporation |
| .SYMBOLS | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SYN | Image-Line | Data Files | SimSynth Document | FL Studio 12 | Image-Line |
| .SYNC | Apple | Data Files | Apple ColorSync File | Apple OS X | Apple |
| .SYNTAX | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SYSLOG | Apple | Data Files | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SZF | Deutsche Automobil Treuhand | Data Files | SilverDAT II Data Exchange Format | SilverDAT II | Deutsche Automobil Treuhand |
| .SZP | PKWare | Data Files | SecureZIP Policy Data | SecureZIP | PKWare |
| .SZS | Nintendo | Data Files | Wii Game Data File | Wiimms SZS Toolset | Nintendo |
| .SZX | Open Source | Data Files | Spectaculator ZX-State Snapshot | Spectaculator | Open Source |
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