| .D2J | Unknown Developer | Developer Files | D2jsp Script File | Unknown Software | Unknown Developer |
| .DA! | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .DA5032 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DAB | Epigon Media Technologies | Audio Files | Digital Audio Broadcasting Audio Data | Unknown Software | Unknown Developer |
| .DANGER | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DARBY | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .DATAGRABBER | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DATALESS | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DATALINKHE | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DATE | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DBU | Unknown Developer | Data Files | Client-Course Manager Database Expansion Update | Unknown Software | Unknown Developer |
| .DB_ | Unknown Developer | CAD Files | CAD File | Unknown Software | Unknown Developer |
| .DCHB1 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DDA | MicroImages | Graphic Files | TNTmips Import File Format | Unknown Software | Unknown Developer |
| .DDI | Unknown Developer | Disk Image Files | DiskDupe Disk Image | Unknown Software | Unknown Developer |
| .DDO | Unknown Developer | Game Files | Tank3D Game Data | Unknown Software | Unknown Developer |
| .DE | Interscape | Page Layout Files | DrawExpress Diagram File | Unknown Software | Unknown Developer |
| .DEFAULT | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DFCOMPONEN | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DFI | Unknown Developer | Font Files | Digifont Outline Font Description File | Unknown Software | Unknown Developer |
| .DFINE | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DFM | Open Source | Text Files | Pascal File | Unknown Software | Unknown Developer |
| .DHR | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DIH | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DISPOSITIO | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DJE | Unknown Developer | Audio Files | MattBatt iAM-player Track List | Unknown Software | Unknown Developer |
| .DK | Unknown Developer | Uncommon Files | Danish Text/localization File | Unknown Software | Unknown Developer |
| .DLFA | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DMJ | Unknown Developer | Uncommon Files | Dustman Selection for Delete File | Unknown Software | Unknown Developer |
| .DMV | Adobe Systems Incorporated | Settings Files | Adobe Acrobat Catalog Data | Unknown Software | Unknown Developer |
| .DNA.XML | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DNAXML | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DOCS | Unknown Developer | Text Files | Document | Unknown Software | Unknown Developer |
| .DOCUMENTAT | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DOO | Atari Corporation | Raster Image Files | Atari Doodle Image | Unknown Software | Unknown Developer |
| .DORE | Unknown Developer | Uncommon Files | Dore Raster Files Format | Unknown Software | Unknown Developer |
| .DOWN | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DOYO000 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DP | Stefan Hagel | Text Files | Text Document | Unknown Software | Unknown Developer |
| .DR9 | Unknown Developer | Uncommon Files | Directory Files | Unknown Software | Unknown Developer |
| .DRAFT | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DRAGONSFUN | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DRIVE | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DRIVERS | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .DRZ | Unknown Developer | Raster Image Files | Draz Paint File | Unknown Software | Unknown Developer |
| .DR_ | Unknown Developer | Uncommon Files | Compressed DRV File Of VFW | Unknown Software | Unknown Developer |
| .DSJ | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .DSSC | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DST- | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DTED | Unknown Developer | Graphic Files | Digital Terrain Elevation Geographical Data File Format | Unknown Software | Unknown Developer |
| .DTR | Swisslog | Data Files | Swisslog Downtime Analyzer Report | Unknown Software | Unknown Developer |
| .DUC | Datel | Game Files | Action Replay Max DS Save File | Unknown Software | Unknown Developer |
| .DUPLICATEZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DVDREGIONC | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .DVDRIP | Unknown Developer | Video Files | DVD Disk Image | Unknown Software | Unknown Developer |
| .DWV | Unknown Developer | Uncommon Files | WAV File | Unknown Software | Unknown Developer |
| .DYNAMO | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .D_ | Unknown Developer | Audio Files | Seqmax Seqprest Compressed Audio File | Unknown Software | Unknown Developer |
| .D_3 | Unknown Developer | Data Files | Polytext Ma'archot Meida Co. S"TaM | Unknown Software | Unknown Developer |
| .D_T | Unknown Developer | Uncommon Files | Eru/erd File | Unknown Software | Unknown Developer |
| .EARTHTIME | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EATF | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EBC | SourceForge | Developer Files | MediaBASIC Compiled Project | Unknown Software | Unknown Developer |
| .EBV | ASH WARE | Data Files | Ash Ware Enhanced Behavior Data | Unknown Software | Unknown Developer |
| .EBX | IBM | Developer Files | Rational Rose 98 Compiled Script | Unknown Software | Unknown Developer |
| .EC | Informix Corporation | Developer Files | Informix ESQL/C Source | Unknown Software | Unknown Developer |
| .ECA | Unknown Developer | CAD Files | ElectroCAD File | Unknown Software | Unknown Developer |
| .ECC | Carsten Gnörlich | Data Files | Dvdisaster Error Correction File | Unknown Software | Unknown Developer |
| .ECELP4800 | Nuera Communications | Settings Files | Nuera ECELP Speech Codec Family | Unknown Software | Unknown Developer |
| .ECELP7470 | Nuera Communications | Audio Files | Nuera Audio File | Unknown Software | Unknown Developer |
| .ECELP9600 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECLIPSEPRO | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECMA | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002PUZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002WOR | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EFC | Unknown Developer | Data Files | EFCoins File | Unknown Software | Unknown Developer |
| .EGT | EagleGet | Uncommon Files | EagleGet Temporary File | Unknown Software | Unknown Developer |
| .EIF | Envex Solutions | Data Files | Envex Import Format File | Unknown Software | Unknown Developer |
| .EIZ | EIAS3D | Graphic Files | Electric Image File Format | Unknown Software | Unknown Developer |
| .EKA | Borland | Data Files | Eureka Internal Data File | Unknown Software | Unknown Developer |
| .EKY | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ELN | Blackboard Collaborate | Data Files | Blackboard Collaborate Note Document | Unknown Software | Unknown Developer |
| .EMJSX | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMK | Elex Media | Backup Files | EMK Compress Archive | Unknown Software | Unknown Developer |
| .EMQ | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EMQZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMS | Intergraph Corporation | Data Files | Intergraph Engineering Modelling System File | Unknown Software | Unknown Developer |
| .EMZJ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EOS | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EP3 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EPV | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .ER2 | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .ERIC | Apple | Data Files | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .EST2015 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ETA | Google | GIS Files | Google Earth Placemark File | Unknown Software | Unknown Developer |
| .ETM | Etreppid Technologies, LLC | Audio Files | eTreppid Audio File | Unknown Software | Unknown Developer |
| .ETW | Enter Tech | Audio Files | Enter Tech Recorded Audio | Unknown Software | Unknown Developer |
| .EV6 | Unknown Developer | Uncommon Files | EV8 Virtual Reality Applications File | Unknown Software | Unknown Developer |
| .EVA | Unknown Developer | Graphic Files | Viz Modeler 3D Scene Archive File | Unknown Software | Unknown Developer |
| .EWZ | Qivx, Inc. | Compressed Files | EdgeWize Compressed Encoded Data File | Unknown Software | Unknown Developer |
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