| .SBN | ESRI | GIS檔案 | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SBX | Dream Design Entertainment Software | 壓縮檔案 | GLBasic Shoebox File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDC | Stardock Corporation | 備份檔案 | Stardock Central Download Archive | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDI | Intuit, Inc. | 資料檔案 | QuickBooks Data File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SDW | LizardTech | GIS檔案 | MrSID World File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHP | Autodesk, Inc. | 三維圖像檔案 | AutoCAD Shape File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SHX | Autodesk, Inc. | CAD檔案 | AutoCAD Compiled Shape File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SID | Valve | 遊戲檔案 | Steam Game Data Backup File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SLD | ESRI (Environmental Systems Research Institute) | GIS檔案 | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SML | ESRI | 開發商檔案 | ARC/INFO Simple Macro Language File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .STN | ON1, Inc. | 向量圖像檔案 | Genuine Fractals Image | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .STYLE | Trimble Inc. | 設置檔案 | SketchUp Style | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SXD | ESRI | GIS檔案 | ArcScene Document | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
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