| .D01 | Yamaha Corporation | Ficheiros de Áudio | OPL2 FM Audio File | Winamp with Ganbatte! Plug-in | Unknown Developer |
| .DAB | Epigon Media Technologies | Ficheiros de Áudio | Digital Audio Broadcasting Audio Data | DMB Player | Epigon Media Technologies |
| .DAW | Hasbro | Ficheiros de Áudio | Hasbro Scrabble CDROM OWL2 List File | Hasbro Scrabble CD-ROM | Hasbro |
| .DB | Dwayne Richard Hipp | Ficheiros de Áudio | Mobile Device Database File | SQLite | Dwayne Richard Hipp |
| .DCF | Sony Mobile Communications | Ficheiros de Áudio | DRM Content Format File | DRM Packager | Sony Mobile Communications |
| .DCM | National Electrical Manufacturers Association (NEMA) | Ficheiros de Áudio | DICOM Image File Format | Adobe Photoshop | Adobe Systems Incorporated |
| .DCT | Microsoft Corporation | Ficheiros de Áudio | Dictionary File | QuarkXPress | Quark Software Inc. |
| .DDA | MicroImages | Ficheiros de Áudio | TNTmips Import File Format | TNTmips | MicroImages |
| .DDT | Sports Interactive | Ficheiros de Áudio | Football Manager Keep Player Data File | Football Manager 2016 | Sports Interactive |
| .DEWF | Macromedia | Ficheiros de Áudio | SoundEdit Recorded Instrument | Awave Studio | FMJ-Software |
| .DF2 | Jenner Fusari | Ficheiros de Áudio | Defractor 2 Instrument | Neurotix Defractor | Jenner Fusari |
| .DFC | Jenner Fusari | Ficheiros de Áudio | Defractor Instrument | Neurotix Defractor | Jenner Fusari |
| .DFF | Zanoza Software | Ficheiros de Áudio | RenderWare Model File | Zanoza ZModeler | Zanoza Software |
| .DFM | Open Source | Ficheiros de Áudio | Pascal File | Notepad++ | Don Ho |
| .DFU | Apple | Ficheiros de Áudio | iOS DFU File | Apple iOS | Apple |
| .DHP | Media Cybernetics | Ficheiros de Áudio | Dr. Halo II-III Bitmap File | Dr. Halo III paint program | Media Cybernetics |
| .DIG | Various Developers | Ficheiros de Áudio | Sound Designer Audio File | Awave Studio | FMJ-Software |
| .DJE | Unknown Developer | Ficheiros de Áudio | MattBatt iAM-player Track List | Unknown Software | Unknown Developer |
| .DJR | Avanquest Software | Ficheiros de Áudio | Ringtone Media Studio DJ Ringtone Project | Avanquest Ringtone Media Suite | Avanquest Software |
| .DKD | Interscape | Ficheiros de Áudio | Karaoke Music File | JBK Karaoke Player | Interscape |
| .DLP | Microsoft Corporation | Ficheiros de Áudio | DirectMusic Producer DLS Data | DirectMusic Producer | Neowin |
| .DLS | Not a Hat / Pete Yandell | Ficheiros de Áudio | Downloadable Sounds File | SimpleSynth | Not a Hat / Pete Yandell |
| .DMC | nModal Solutions Inc. | Ficheiros de Áudio | Datamartist Data Canvas File | nModal Solutions Datamartist | nModal Solutions Inc. |
| .DMF | Geosystem | Ficheiros de Áudio | Geosystem Digitals Map File | Geosystem Digitals | Geosystem |
| .DRA | Nuance | Ficheiros de Áudio | Dragon NaturallySpeaking Voice | Dragon NaturallySpeaking | Nuance |
| .DRO | Open Source | Ficheiros de Áudio | DOSBox Raw OPL Format | DOSBox | Open Source |
| .DRX | Adobe Systems Incorporated | Ficheiros de Áudio | Adobe Photoshop Tutorial Data | Adobe Photoshop | Adobe Systems Incorporated |
| .DS | DAZ 3D | Ficheiros de Áudio | DAZ Studio 1/2 Script | DAZ Studio | DAZ 3D |
| .DSF | DAZ 3D | Ficheiros de Áudio | DAZ Studio Asset File | DAZ Studio | DAZ 3D |
| .DSM | Open Source | Ficheiros de Áudio | Digital Sound Module | ModPlug Player | Open Source |
| .DSP | Open Source | Ficheiros de Áudio | Dynamic Studio Professional Module | ModPlug Player | Open Source |
| .DSS | The International Voice Association (IVA) | Ficheiros de Áudio | Digital Speech Standard File | DSS Player Lite | Olympus Corporation |
| .DTG | Desktop Music | Ficheiros de Áudio | Desktop Guitar Score File | Desktop Guitar | Desktop Music |
| .DTM | Prodatron | Ficheiros de Áudio | DigiTrakker Audio Module | CocoModX | Open Source |
| .DTS | CyberLink | Ficheiros de Áudio | DTS Encoded Audio File | CyberLink PowerDVD | CyberLink |
| .DTSHD | Digital Theater Systems (DTS) Inc. | Ficheiros de Áudio | DTS-HD Master Audio File | DTS-HD MASTER AUDIO SUITE | Digital Theater Systems (DTS) Inc. |
| .DUB | Interscape | Ficheiros de Áudio | Tuningwrench Audio Utility Compressed Audio | Tuningwrench | Interscape |
| .DVA | Leitch Technology | Ficheiros de Áudio | DPS Velocity Split Audio | DPS Velocity | Leitch Technology |
| .DVC | IBM | Ficheiros de Áudio | Lotus 1-2-3 Data | Lotus 1-2-3 | IBM |
| .DVF | Sony | Ficheiros de Áudio | Sony Digital Voice File | Microsoft Windows Media Player | Microsoft Corporation |
| .DVW | Dektron | Ficheiros de Áudio | Dektron Digital Voice Recorder Audio Data | Dektron Digital Voice Recorder | Dektron |
| .DW | Un4seen Developments | Ficheiros de Áudio | David Whittaker Audio File | DeliPlayer | Open Source |
| .DWA | Alex Gavrilov | Ficheiros de Áudio | Digital Waveform Archiver Audio File | DWA Coder | DWA Coder |
| .DWD | DiamondWare Ltd. | Ficheiros de Áudio | DiamondWare Digital Audio File | Wi-Fone | DiamondWare Ltd. |
| .D_ | Unknown Developer | Ficheiros de Áudio | Seqmax Seqprest Compressed Audio File | Unknown Software | Unknown Developer |
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