| .SSV | Seavus | Arquivos de jogos | Seavus Secure Project File | Seavus Project Viewer | Seavus |
| .ST3 | National Instruments | Arquivos de jogos | SPICE Status Data | Spice | National Instruments |
| .STA | Dassault Systèmes | Arquivos de jogos | ABAQUS Status File | ABAQUS software suite | Dassault Systèmes |
| .STG | Microsoft Corporation | Arquivos de jogos | ActiveSync Backup File | Microsoft ActiveSync | Microsoft Corporation |
| .STL | 3D Systems | Arquivos de jogos | Stereolithography File | Creo Parametric 3D Modeling Software | PTC |
| .STN | ON1, Inc. | Arquivos de jogos | Genuine Fractals Image | Adobe Photoshop | Adobe Systems Incorporated |
| .STO | Ecru Software | Arquivos de jogos | PRO100 3D Interior Design Project | Ecru Software PRO100 | Ecru Software |
| .STP | Unknown Developer | Arquivos de jogos | STEP 3D CAD File | CATIA | Dassault Systèmes |
| .STR | dBase, LLC | Arquivos de jogos | dBASE Structure List Object File | dBase | dBase, LLC |
| .STS | DuoS DSEMU | Arquivos de jogos | DuoS DSEMU Saved State File | DuoS DSEMU | Unknown Developer |
| .STUFF | CCP Games | Arquivos de jogos | EVE Online Data File | EVE Online | CCP Games |
| .SUB | URUWORKS | Arquivos de jogos | Subtitle File | CyberLink PowerDVD | CyberLink |
| .SUD | Aivosto Oy | Arquivos de jogos | Super Project Analyzer Data File | Super Project Analyzer | Aivosto Oy |
| .SV | Playsoft | Arquivos de jogos | Roland Garros Tennis File | Roland Garros Tennis Champions | Playsoft |
| .SV1 | Atari Corporation | Arquivos de jogos | RollerCoaster Tycoon Saved Game File | RollerCoaster Tycoon | Chris Sawyer |
| .SV4 | Chris Sawyer | Arquivos de jogos | RollerCoaster Tycoon Saved Game | RollerCoaster Tycoon | Chris Sawyer |
| .SV5 | Atari Corporation | Arquivos de jogos | Chris Sawyer's Locomotion Saved Game File | RollerCoaster Tycoon | Chris Sawyer |
| .SV6 | Chris Sawyer | Arquivos de jogos | RollerCoaster Tycoon 2 Saved Game | RollerCoaster Tycoon 2: Triple Thrill Pack | Chris Sawyer |
| .SV7 | Nintendo | Arquivos de jogos | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SV8 | Atari Corporation | Arquivos de jogos | RollerCoaster Tycoon Game Data | RollerCoaster Tycoon | Chris Sawyer |
| .SVE | Simutrans Development Team | Arquivos de jogos | Simutrans Saved Game | Simutrans | Simutrans Development Team |
| .SVG | Nintendo | Arquivos de jogos | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SVH | IEEE Xplore | Arquivos de jogos | SystemVerilog Source Code Header File | Microsoft Notepad | Microsoft Corporation |
| .SVS | Nintendo | Arquivos de jogos | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
| .SVT | Runic Games | Arquivos de jogos | Torchlight Saved Game File | TorchTools | Open Source |
| .SWC | Adobe Systems Incorporated | Arquivos de jogos | Flex Components Archive | Adobe Animate CC 2017 | Adobe Systems Incorporated |
| .SWE | Electronic Arts | Arquivos de jogos | NHL Ice Hockey 2002 Required Data | NHL 2002 | Electronic Arts |
| .SWV | Microsoft Corporation | Arquivos de jogos | Microsoft Sidewinder Game Voice Settings File | SideWinder Game Voice Utility | Microsoft Corporation |
| .SWW | Ubisoft | Arquivos de jogos | Anno Saved Game | ANNO 2070 | Ubisoft Blue Byte |
| .SXT | FMJ-Software | Arquivos de jogos | Propellerheads Reason 2 NN-XT Sound Data | FMJ-Software Awave Audio | FMJ-Software |
| .SYB | Microïds | Arquivos de jogos | Syberia II Game Archive File | Syberia II | Microïds |
| .SYN | Image-Line | Arquivos de jogos | SimSynth Document | FL Studio 12 | Image-Line |
| .SYSTEM | Open Source | Arquivos de jogos | Vega Strike Virtual System File | Microsoft Notepad | Microsoft Corporation |
| .SZS | Nintendo | Arquivos de jogos | Wii Game Data File | Wiimms SZS Toolset | Nintendo |
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