| .M | MathWorks | File sviluppatore | MATLAB Source Code File | FMPMD2000 | Unknown Developer |
| .M2 | Unknown Developer | File audio | PC-98 Game Music File | FMPMD2000 | Unknown Developer |
| .M3K | Unknown Developer | File compressi | Interactive Digital Content File | Unknown Software | Unknown Developer |
| .M3V | Unknown Developer | File audio | DJ Mix Pro Playlist | DJ Mix Pro | Unknown Developer |
| .M5D | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .M9D | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MAC2 | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MACRO | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MAILBOX | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MAPS | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MARIO | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MAU | Unknown Developer | File vari | Media Attachment Unit | Unknown Software | Unknown Developer |
| .MBL | Vernier Software & Technology | File di dati | Logger Pro Data File | Multi-Batch | Unknown Developer |
| .MBZ | Unknown Developer | File con plugin | Pogoshell NES Emulator Plugin | PogoShell | Unknown Developer |
| .MCH | Interscape | File di settaggi | Machinery HDR Effects | Unknown Software | Unknown Developer |
| .MCV | Visicom Media Inc | File di settaggi | ManyCam Effect File | Unknown Software | Unknown Developer |
| .MC_ | Unknown Developer | File compressi | Musicato Compressed File | Unknown Software | Unknown Developer |
| .MD | Various Developers | File sviluppatore | Markdown Documentation File | mdcd10.arc | Unknown Developer |
| .MDL | MathWorks | File di dati | MathWorks Simulink Model | mdl2obj tool | Unknown Developer |
| .MD_ | Unknown Developer | File di settaggi | Visc15 Adressen Setup File | Unknown Software | Unknown Developer |
| .ME | Unknown Developer | File vari | Temporary Delete Me File | Unknown Software | Unknown Developer |
| .ME1 | Unknown Developer | File di dati | 21 Sample Winexam File | Unknown Software | Unknown Developer |
| .ME2 | Unknown Developer | File vari | Uncommon File Extension | Unknown Software | Unknown Developer |
| .MEI | Unknown Developer | File vari | Uncommon File Extension | Unknown Software | Unknown Developer |
| .MEK | Unknown Developer | File vari | Uncommon File Extension | Unknown Software | Unknown Developer |
| .MEMORY | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MERLIN | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MESSAGES | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .METAL | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MFC | Unknown Developer | File vari | Mankind File | Unknown Software | Unknown Developer |
| .MFO | Perl Express Group | File di dati | Perl ModInfo Descriptor File | Unknown Software | Unknown Developer |
| .MGW | Unknown Developer | File di dati | Microgateway Policy Implementation Data | Microgateway | Unknown Developer |
| .MHW | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MICE | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MISC | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MJM | Unknown Developer | File di dati | JDF Data Exchange Format | Unknown Software | Unknown Developer |
| .MK8 | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MLI | Unknown Developer | File di dati | Encyclopedia Media List | Unknown Software | Unknown Developer |
| .MLTV | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MMV | Sony | File video | MicroMV Video File | Unknown Software | Unknown Developer |
| .MNW | Unknown Developer | File vari | Menu File | Unknown Software | Unknown Developer |
| .MODEM | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MOJ | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MOUSE | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MP4S | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MP6 | Unknown Developer | File di dati | CS225 MP6 Huffman Encoding Text Data | Unknown Software | Unknown Developer |
| .MP_ | Open Source | File audio | Mobile Phone Sound File | P2k Commander | Unknown Developer |
| .MQF | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MRA | Unknown Developer | File audio | VilagRadio Recorded Radio Program | Unknown Software | Unknown Developer |
| .MRS | MAIET Entertainment | File di giochi | GunZ Game Data File | MRS Decompiler | Unknown Developer |
| .MS-LOCKSCREENCOMPONENT-PRIMARY | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MSA | Unknown Developer | File compressi | Magic Shadow Archiver Atari Disk Image | Magic Shadow Archiver | Unknown Developer |
| .MSB | Oracle Corporation | File di dati | Oracle Binary Message File | Oracle .msb files unpacker | Unknown Developer |
| .MSEPUB | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MSG2 | Apple | File di dati | Golden Orchard Apple II CD Rom File | Unknown Software | Unknown Developer |
| .MSO | Microsoft Corporation | File di dati | Microsoft Organization Chart Data File | Should Not Be Opened Manually | Unknown Developer |
| .MT9 | Electronics and Telecommunications Research Institute | File audio | Music 2.0 Song | Unknown Software | Unknown Developer |
| .MTC | Make The Cut, LLC | File con layout di pagina | Make The Cut! Project | Unknown Software | Unknown Developer |
| .MTV | MyMPX.org | File video | MTV Video Format File | Unknown Software | Unknown Developer |
| .MUK | Unknown Developer | File audio | Multak Mini 8162 Encoded Audio Karaoke | Unknown Software | Unknown Developer |
| .MUV | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MUZIIC | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MV3 | Unknown Developer | File audio | Audio Data | Unknown Software | Unknown Developer |
| .MVO | Unknown Developer | File grafici | A Graphic File | Unknown Software | Unknown Developer |
| .MWR | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
| .MWV | Unknown Developer | File di dati | Media Works Data | Unknown Software | Unknown Developer |
| .MW_ | Unknown Developer | File audio | Audio Utility Midimach Compressed File | Unknown Software | Unknown Developer |
| .MYW | Unknown Developer | File con immagini vettoriali | MyWorld Education Drawing | Unknown Software | Unknown Developer |
| .MZF | Unknown Developer | File compressi | MediaZip Archive | MediaZip | Unknown Developer |
| .M_S | Unknown Developer | File vari | Unknown File Type | Unknown Software | Unknown Developer |
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