| .E78 | IBM | Uncommon Files | IBM 3270 Terminal Emulator Screen Layout Definition | QWS3270 PLUS | Jolly Giant Inc |
| .EARTHTIME | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EB | Procedimientos-Uno, S.L. | Uncommon Files | EBwin Project | EBwin | Procedimientos-Uno, S.L. |
| .EBN | Philips 3D Solutions | Uncommon Files | Philips Firmware Update File | Windows Phone Device Manager | Open Source |
| .ECELP9600 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECLIPSEPRO | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECMA | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002PUZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ECW2002WOR | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EDC | Inv Softworks | Uncommon Files | Kryptel Lite Encrypted File | Kryptel | Inv Softworks |
| .EFL | National Federation of the Blind | Uncommon Files | External Format Language File | NFBTRANS | National Federation of the Blind |
| .EGT | EagleGet | Uncommon Files | EagleGet Temporary File | EagleGet | EagleGet |
| .EHP | Software Steward, LLC | Uncommon Files | Help Steward Project | Help Steward | Software Steward, LLC |
| .EIDI | XnSoft | Uncommon Files | Electric Image EIDI File | XnView MP | XnSoft |
| .EKY | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMAIL | Microsoft Corporation | Uncommon Files | Outlook Express Email Message | Microsoft Outlook Express | Microsoft Corporation |
| .EMJSX | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMQ | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EMQZ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EMR | Unknown Developer | Uncommon Files | Emrite Data File | Emrite | Unknown Developer |
| .EMZJ | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ENC | Smith Micro Software | Uncommon Files | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .ENCRYPTED | Malwarebytes | Uncommon Files | Crypt0L0cker Ransomware Infected Files | Malwarebytes Anti-Malware program | Malwarebytes |
| .ENF | Thomson Reuters Corporation | Uncommon Files | EndNote Filter File | EndNote | Thomson Reuters Corporation |
| .EOS | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EP3 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .EPRTX | Microsoft Corporation | Uncommon Files | Microsoft XPS Document Related File | Microsoft XPS Viewer | Microsoft Corporation |
| .EPT | Adobe Systems Incorporated | Uncommon Files | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .EPV | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .EQN | Altium | Uncommon Files | GAL Equation File | Altium Designer | Altium |
| .ER3 | DigiSoft Innovations | Uncommon Files | An Unknown Apple II File | Golden Orchard | DigiSoft Innovations |
| .ERL | INCA Internet | Uncommon Files | GameGuard Error Log File | GameGuard | INCA Internet |
| .ERR | Microsoft Corporation | Uncommon Files | Error Log File | Microsoft Notepad | Microsoft Corporation |
| .ESD | Microsoft Corporation | Uncommon Files | Windows Electronic Software Download File | Microsoft Windows | Microsoft Corporation |
| .EST2015 | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .ETE | Vumingo | Uncommon Files | Exam Testing Engine Test | Exam Testing Engine | Vumingo |
| .ETF | NetScape | Uncommon Files | Enriched Text Format E-mail Message | GNU Emacs | GNU Project |
| .EUG | DigiSoft Innovations | Uncommon Files | An Unknown Apple II File | Golden Orchard | DigiSoft Innovations |
| .EUS | Open Source | Uncommon Files | eDonkey2000 Serverlist Tool | EDonkey2000 | Open Source |
| .EV6 | Unknown Developer | Uncommon Files | EV8 Virtual Reality Applications File | Unknown Software | Unknown Developer |
| .EVENT | Corel | Uncommon Files | Corel Cataloged Folder File | Corel AfterShot | Corel |
| .EVK | Az-Tech Software | Uncommon Files | Everlock Copy File | Az-Tech Everlock | Az-Tech Software |
| .EXD | Microsoft Corporation | Uncommon Files | Control Information Cache File | Microsoft Excel | Microsoft Corporation |
| .EXT | Symantec Corporation | Uncommon Files | Norton Commander Extension | Norton Commander | Symantec Corporation |
| .EXTRA | Google | Uncommon Files | Google BreakPad Crash Log Extra File | Mozilla Firefox | Mozilla |
| .EZO | Astonsoft | Uncommon Files | EZOutlookSync Pro Database File | EZOutlookSync Pro | Astonsoft |
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