| .SBE | Safer Networking Ltd. | Instellingsbestanden | Spybot Exclude Data | Spybot - Search & Destroy | Safer Networking Ltd. |
| .SBS | Allegorithmic | Instellingsbestanden | Substance Package | Substance Designer | Allegorithmic |
| .SBV | Superbase Software | Instellingsbestanden | Superbase Form Definition File | Superbase | Papatuo Holdings Ltd |
| .SBX | Dream Design Entertainment Software | Instellingsbestanden | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SCH | Autodesk, Inc. | Instellingsbestanden | EAGLE Schematics File | Autodesk EAGLE | Autodesk, Inc. |
| .SCHEMAS | Open Source | Instellingsbestanden | GConf Schema Definition File | GNU Emacs | GNU Project |
| .SDC | Stardock Corporation | Instellingsbestanden | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDD | Programming Sunrise | Instellingsbestanden | Smart Diary Suite Data File | Smart Diary Suite | Programming Sunrise |
| .SDI | Intuit, Inc. | Instellingsbestanden | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDM | Oracle Corporation | Instellingsbestanden | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SED | Microsoft Corporation | Instellingsbestanden | IExpress Self Extraction Directive File | Microsoft IExpress Wizard | Microsoft Corporation |
| .SEQU | Adobe Systems Incorporated | Instellingsbestanden | Adobe Acrobat Sequence File | Adobe Acrobat DC | Adobe Systems Incorporated |
| .SES | Adobe Systems Incorporated | Instellingsbestanden | Audition Session File | Adobe Audition | Adobe Systems Incorporated |
| .SET | Xerox | Instellingsbestanden | Document Library Property Set File | Xerox Library Administration Tool | Fuji Xerox |
| .SETTINGCONTENT-MS | Microsoft Corporation | Instellingsbestanden | Microsoft Windows 8.1 Configuration Data | Microsoft Windows 8 | Microsoft Corporation |
| .SETTINGS | Microsoft Corporation | Instellingsbestanden | Microsoft Visual Studio Settings File | Microsoft Visual Studio | Microsoft Corporation |
| .SFO | Interscape | Instellingsbestanden | PSP Game Parameters File | PBP Unpacker | Unknown Developer |
| .SFS | Open Source | Instellingsbestanden | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SG | Unknown Developer | Instellingsbestanden | SG-1000 Game ROM File | Kega Fusion | Steve Snake |
| .SGS | Open Source | Instellingsbestanden | WinDS PRO Data | WinDS PRO | Open Source |
| .SGT | IBM | Instellingsbestanden | SPSS Chart Template File | IBM SPSS | IBM |
| .SHADOW | Neuber Software | Instellingsbestanden | FontTwister Shadow File | FontTwister | Neuber Software |
| .SHH | Adobe Systems Incorporated | Instellingsbestanden | Adobe Photoshop Shadow/Highlight Settings | Adobe Photoshop CC | Adobe Systems Incorporated |
| .SIF | Microsoft Corporation | Instellingsbestanden | Windows Setup Information File | Microsoft Notepad | Microsoft Corporation |
| .SIZ | Oracle Corporation | Instellingsbestanden | Oracle 7 Configuration File | Oracle Database | Oracle Corporation |
| .SKI | Motorola | Instellingsbestanden | Motorola Phone Skin File | Apache OpenOffice | Apache Software Foundation |
| .SKIN | Microsoft Corporation | Instellingsbestanden | ASP.NET Skin File | Microsoft Visual Studio | Microsoft Corporation |
| .SKL | Autodesk, Inc. | Instellingsbestanden | Maya Skeleton File | Autodesk Maya | Autodesk, Inc. |
| .SKN | Avant Force | Instellingsbestanden | Avant Browser Skin File | Avant Browser | Avant Force |
| .SKP | Trimble Inc. | Instellingsbestanden | SketchUp Document | SketchUp | Trimble Inc. |
| .SKZ | SuperKaramba Project | Instellingsbestanden | SuperKaramba Theme | SuperKaramba | SuperKaramba Project |
| .SL | SourceForge | Instellingsbestanden | Unix Software License File | Vi | SourceForge |
| .SLT | Mozilla | Instellingsbestanden | Mozilla User Profile Folder | Mozilla Firefox | Mozilla |
| .SMR | Uberware | Instellingsbestanden | Smedge2 Job Settings File | Smedge2 | Uberware |
| .SMS | Sega | Instellingsbestanden | Sega Master System ROM | Kega Fusion | Steve Snake |
| .SMT | Intuit, Inc. | Instellingsbestanden | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SMX | MakeMusic, Inc. | Instellingsbestanden | SmartMusic XML File | SmartMusic | MakeMusic, Inc. |
| .SNC | Swiftpage, Inc. | Instellingsbestanden | ACT! E-mail/folder Synchronization File | Act! | Swiftpage, Inc. |
| .SNX | Pi Innovo | Instellingsbestanden | PISnoop Workspace File | PiSnoop | Pi Innovo |
| .SOC | Apache Software Foundation | Instellingsbestanden | OpenOffice.org Configuration File | Apache OpenOffice | Apache Software Foundation |
| .SOL | Adobe Systems Incorporated | Instellingsbestanden | Flash Local Shared Object File | Adobe Flash Player | Adobe Systems Incorporated |
| .SPF | StorageCraft | Instellingsbestanden | ShadowProtect Full Backup File | VMware vCenter Converter | VMware |
| .SPFX | Sorenson Media | Instellingsbestanden | Squeeze Presets File | Squeeze | Sorenson Media |
| .SPJ | IBM | Instellingsbestanden | SPSS Production Job File | IBM SPSS | IBM |
| .SPN | Corel | Instellingsbestanden | Corel WordPerfect Distribution Definition | Corel WordPerfect | Corel |
| .SPS | IBM | Instellingsbestanden | SPSS Program File | IBM SPSS | IBM |
| .SQD | SparkPath Technologies | Instellingsbestanden | Configuration Settings File | SP Debugger for SQR | SparkPath Technologies |
| .SRF | NewTek | Instellingsbestanden | LightWave Surface File | LightWave 3D | NewTek |
| .SRP | Check Point Software Technologies Ltd. | Instellingsbestanden | Checkpoint Exported VPN Client Information File | ZoneAlarm Pro | Check Point Software Technologies Ltd. |
| .SRS | Microsoft Corporation | Instellingsbestanden | Outlook Send/Receive Settings File | Microsoft Outlook | Microsoft Corporation |
| .SRV | FBB Software | Instellingsbestanden | FBB Initialization Settings | FBB Packet-Radio BBS | FBB Software |
| .SSB | Joshua Cannon Butcher | Instellingsbestanden | Simply Safe Backup Archive | Simply Safe Backup | Joshua Cannon Butcher |
| .SSL | Bethesda Softworks | Instellingsbestanden | Fallout Script | Fallout Script Editor | Jargo |
| .SSS | Stardock Corporation | Instellingsbestanden | WindowBlinds Substyle File | WindowBlinds | Stardock Corporation |
| .SSZ | Open Source | Instellingsbestanden | Spider Player Skin File | Spider Player Pro | Open Source |
| .STB | Autodesk, Inc. | Instellingsbestanden | AutoCAD Plot Style Table File | Autodesk AutoCAD | Autodesk, Inc. |
| .STC | Adobe Systems Incorporated | Instellingsbestanden | Contribute Connection Key File | Adobe Contribute 6.5 | Adobe Systems Incorporated |
| .STD | Oracle Corporation | Instellingsbestanden | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STE | Adobe Systems Incorporated | Instellingsbestanden | Dreamweaver Site Settings File | Microsoft Notepad | Microsoft Corporation |
| .STF | Microsoft Corporation | Instellingsbestanden | Exchange 2000 Server Temporary File | Microsoft Exchange Server | Microsoft Corporation |
| .STP | Unknown Developer | Instellingsbestanden | STEP 3D CAD File | CATIA | Dassault Systèmes |
| .STT | Microsoft Corporation | Instellingsbestanden | Streets & Trips Map Template | Microsoft AutoRoute | Microsoft Corporation |
| .STY | Jørgen Sørensen / Jososoft | Instellingsbestanden | Yamaha/Korg Keyboard Style | Style Fixer | Jørgen Sørensen / Jososoft |
| .STYLE | Trimble Inc. | Instellingsbestanden | SketchUp Style | SketchUp | Trimble Inc. |
| .SUBLIME-KEYMAP | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Keymap Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-PROJECT | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Project | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SESSION | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Session Data | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SETTINGS | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SNIPPET | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Snippet | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-SYNTAX | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Syntax Definition Format | Sublime Text | Sublime HQ Pty Ltd |
| .SUBLIME-WORKSPACE | Sublime HQ Pty Ltd | Instellingsbestanden | Sublime Text Workspace Settings | Sublime Text | Sublime HQ Pty Ltd |
| .SUITE | Stardock Corporation | Instellingsbestanden | Stardock WinStyles Suite | ZipZag | Open Source |
| .SVP | SwiftView, Inc. | Instellingsbestanden | SwiftView Command File | SwiftView | SwiftView, Inc. |
| .SVS | Nintendo | Instellingsbestanden | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
| .SWE | Electronic Arts | Instellingsbestanden | NHL Ice Hockey 2002 Required Data | NHL 2002 | Electronic Arts |
| .SZ | Nullsoft | Instellingsbestanden | Winamp Classic Skin Download | Nullsoft Winamp | Nullsoft |
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