| .USR | FileMaker Inc. | Instellingsbestanden | FileMaker Pro Database File | FileMaker Pro | FileMaker Inc. |
| .UTI | BioWare | Instellingsbestanden | Bioware Aurora Item Data | BioWare Neverwinter Nights | BioWare |
| .UTS | BioWare | Instellingsbestanden | BioWare Aurora Game Engine Sound File | BioWare Neverwinter Nights | BioWare |
| .UVOPT | Keil | Instellingsbestanden | µVision Project Options | µVision4 | Keil |
| .UVOPTX | Keil | Instellingsbestanden | µVision Configuration | µVision4 | Keil |
| .VBOX | Oracle Corporation | Instellingsbestanden | Oracle VM VirtualBox Settings File | Oracle VM VirtualBox | Oracle Corporation |
| .VCA | Interscape | Instellingsbestanden | VAKCER Project Tracker Add-in | VAKCER Project Tracker | Interscape |
| .VCF | Palm | Instellingsbestanden | VCard File | Microsoft Outlook Express | Microsoft Corporation |
| .VCL | Open Source | Instellingsbestanden | Varnish Configuation File | Varnish Cache | Open Source |
| .VCPREF | Symantec Corporation | Instellingsbestanden | Norton Antivirus Preferences File | Norton Security | Symantec Corporation |
| .VCW | Microsoft Corporation | Instellingsbestanden | eMbedded Visual C++ Workspace File | Microsoft Visual Studio | Microsoft Corporation |
| .VFO | Silicon Graphics, Inc. | Instellingsbestanden | Silicon Graphics Onyx2 Video Format Combiner File | Video Format Combiner | Silicon Graphics, Inc. |
| .VIM | Bram Moolenaar | Instellingsbestanden | Vim Settings File | Vim | Bram Moolenaar |
| .VLT | zilliondigits | Instellingsbestanden | WinVault File Archive | WinVault | zilliondigits |
| .VMC | Microsoft Corporation | Instellingsbestanden | Windows Virtual Machine Configuration File | VMware Workstation | VMware |
| .VMT | VMware | Instellingsbestanden | VMware Configuration File | VMware Workstation | VMware |
| .VMTM | VMware | Instellingsbestanden | VMware Team Data File | VMware Workstation | VMware |
| .VMX | VMware | Instellingsbestanden | VMware Configuration File | VMware Workstation | VMware |
| .VMXF | VMware | Instellingsbestanden | VMware Team Member File | VMware Workstation | VMware |
| .VPH | optikVerve Labs | Instellingsbestanden | VirtualPhotographer Custom Settings | Adobe Photoshop | Adobe Systems Incorporated |
| .VPL | Unknown Developer | Instellingsbestanden | Karaoke Player Playlist | vanBasco's Karaoke Player | Open Source |
| .VPS | H+H Software GmbH | Instellingsbestanden | Virtual CD Copy Template | H+H Software Virtual CD | H+H Software GmbH |
| .VQS | Datapath | Instellingsbestanden | Datapath X4 Configuration File | Datapath X4 | Datapath |
| .VRE | ASG Technologies | Instellingsbestanden | ASG Remote Desktop Settings | ASG-Remote Desktop | ASG Technologies |
| .VRP | Incendo Technology | Instellingsbestanden | Vectir Profile Template File | Vectir | Incendo Technology |
| .VSC | McAfee, Inc. | Instellingsbestanden | McAfee VirusScan Configuration File | McAfee VirusScan Enterprise | McAfee, Inc. |
| .VSIXLANGPACK | Microsoft Corporation | Instellingsbestanden | Microsoft Visual Studio Localised VSIX Package | Microsoft Visual Studio | Microsoft Corporation |
| .VSPROPS | Microsoft Corporation | Instellingsbestanden | Microsoft Visual Studio Project Property Sheet File | Microsoft Visual Studio | Microsoft Corporation |
| .VSPSCC | Microsoft Corporation | Instellingsbestanden | Visual Studio Project Source Control Data | Microsoft Visual Studio | Microsoft Corporation |
| .VSSETTINGS | Microsoft Corporation | Instellingsbestanden | Visual Studio Settings File | Microsoft Visual Studio | Microsoft Corporation |
| .VSW | Microsoft Corporation | Instellingsbestanden | Visio Workspace File | Microsoft Visio 2016 | Microsoft Corporation |
| .VUE | E-on Software, Inc. | Instellingsbestanden | Vue Scene File | E-on Vue | E-on Software, Inc. |
| .VUI | Jeppesen Marine, Inc. | Instellingsbestanden | Visual Navigation Suite Exported Settings | Visual Navigation Suite | Jeppesen Marine, Inc. |
| .VWP | Raven software | Instellingsbestanden | Vehicle Weapon File | Raven Software Star Wars Jedi Knight: Jedi Academy | Valve |
| .VXP | Interscape | Instellingsbestanden | Mobile Application File | Mediatek MRE SDK | MediaTek |
| .W3D | Adobe Systems Incorporated | Instellingsbestanden | Adobe Shockwave 3D File | Adobe Director | Adobe Systems Incorporated |
| .WAT | IBM | Instellingsbestanden | IBM Voice Type Languages Map Data | IBM Voice Type | IBM |
| .WB4 | Stardock Corporation | Instellingsbestanden | WindowBlinds Default Skin | WindowBlinds | Stardock Corporation |
| .WC | Valve | Instellingsbestanden | Valve Hammer Configuration File | Valve Hammer Editor | Valve |
| .WCR | Open Source | Instellingsbestanden | Ergane Configuration File | Ergane | Open Source |
| .WCX | Microsoft Corporation | Instellingsbestanden | RemoteApp And Desktop Connections Configuration File | Remote Desktop Manager | Devolutions |
| .WCZ | SoftShape | Instellingsbestanden | Chameleon Clock Wallpaper File | Chameleon Clock | SoftShape |
| .WFC | Microsoft Corporation | Instellingsbestanden | Windows Wireless Network Settings File | MacroMates TextMate | MacroMates |
| .WFP | Turtle Beach Corporation | Instellingsbestanden | WaveFront Program File | Turtle Beach WaveFront Software | Turtle Beach Corporation |
| .WFW | Microsoft Corporation | Instellingsbestanden | Windows Firewall Policy File | Microsoft Windows Server 2016 | Microsoft Corporation |
| .WFX | Adobe Systems Incorporated | Instellingsbestanden | Adobe User Keyboard Shortcut Settings | Adobe Creative Cloud | Adobe Systems Incorporated |
| .WIF | Canyon Art | Instellingsbestanden | Weaving Interchange Format File | Art WeaveIt (Art iWeaveIt for iOS and Android) | Canyon Art |
| .WLM | Pierre-Emmanuel Gougelet | Instellingsbestanden | CompW Image Format File | XnView MP | XnSoft |
| .WME | Microsoft Corporation | Instellingsbestanden | Windows Media Encoder Session File | Microsoft Windows Media Encoder 9 | Microsoft Corporation |
| .WMS | Microsoft Corporation | Instellingsbestanden | Windows Media Skin | Microsoft Windows Media Player | Microsoft Corporation |
| .WMZ | Microsoft Corporation | Instellingsbestanden | Compressed Windows Media Player Skin | Microsoft Windows Media Player | Microsoft Corporation |
| .WPJ | Watcom International Corporation | Instellingsbestanden | Watcom C/C++ Project | Watcom C/C++ | Open Source |
| .WPP | Serif | Instellingsbestanden | WebPlus Project File | Serif WebPlus | Serif |
| .WPS | Kingsoft | Instellingsbestanden | Kingsoft Writer Document | WPS Office | Kingsoft |
| .WPZ | Naviter | Instellingsbestanden | SeeYou Waypoint File | SeeYou | Naviter |
| .WS | MicroPro International Corp. | Instellingsbestanden | WordStar Document | Corel WordPerfect X8 | Corel |
| .WSA | Sonicle | Instellingsbestanden | WebSynth Media File | WebSynth | Sonicle |
| .WSP | Microsoft Corporation | Instellingsbestanden | SharePoint Solution Package | Microsoft Visual Studio | Microsoft Corporation |
| .WSS | Microsoft Corporation | Instellingsbestanden | Microsoft Windows Sound System File | Microsoft Windows | Microsoft Corporation |
| .WSW | Aignes | Instellingsbestanden | WebSite-Watcher Bookmark | WebSite-Watcher | Aignes |
| .WS_ | Unknown Developer | Instellingsbestanden | Visc15 Adressen Setup File | Unknown Software | Unknown Developer |
| .WWK | Corel Corporation | Instellingsbestanden | Corel WordPerfect Keyboard Layout File | Corel WordPerfect | Corel |
| .WWP | Microsoft Corporation | Instellingsbestanden | Microsoft Works Wizards File | Microsoft Works | Microsoft Corporation |
| .WWS | Microsoft Corporation | Instellingsbestanden | Microsoft Works Wizards File | Microsoft Works | Microsoft Corporation |
| .XC2 | Haliplex Communications | Instellingsbestanden | DACCS Configuration File | HPXView | Haliplex Communications |
| .XCI | Adobe Systems Incorporated | Instellingsbestanden | Adobe Reader Font Mapping File | Adobe Reader | Adobe Systems Incorporated |
| .XCU | Apache Software Foundation | Instellingsbestanden | OpenOffice.org Configuration File | Apache OpenOffice | Apache Software Foundation |
| .XDC | Adobe Systems Incorporated | Instellingsbestanden | Adobe Acrobat Printer Description | Adobe Acrobat DC | Adobe Systems Incorporated |
| .XDR | Microsoft Corporation | Instellingsbestanden | XML-Data Reduced File | Microsoft Notepad | Microsoft Corporation |
| .XEE | Microsoft Corporation | Instellingsbestanden | Microsoft Expression Encoder Preset | Expression Encoder | Microsoft Corporation |
| .XEM | X-Genics Limited | Instellingsbestanden | eManager Metered Units | X-Genics eManager | X-Genics Limited |
| .XEP | X-Genics Limited | Instellingsbestanden | eManager File Packaging Information | X-Genics eManager | X-Genics Limited |
| .XES | X-Genics Limited | Instellingsbestanden | eManager Skins Definition | X-Genics eManager | X-Genics Limited |
| .XET | X-Genics Limited | Instellingsbestanden | eManager Process Definition | X-Genics eManager | X-Genics Limited |
| .XEV | X-Genics Limited | Instellingsbestanden | eManager Auto-Update File | X-Genics eManager | X-Genics Limited |
| .XGS | Microsoft Corporation | Instellingsbestanden | XACT Global Settings File | Microsoft XACT | Microsoft Corporation |
| .XIP | Apple | Instellingsbestanden | MacOS Signed Archive | Apple Archive Utility | Apple |
| .XJS | Newforms Technologies | Instellingsbestanden | Jindent Settings File | Jindent | Newforms Technologies |
| .XLB | Microsoft Corporation | Instellingsbestanden | Excel Toolbars File | Microsoft Excel | Microsoft Corporation |
| .XM2 | LexisNexis | Instellingsbestanden | TextMap Version 2 Case Format File | TextMap | LexisNexis |
| .XMS | Alexander Gross | Instellingsbestanden | Music Studio Project | Alexander Gross Music Studio | Alexander Gross |
| .XPF | Open Source | Instellingsbestanden | Linux MultiMedia Studio Preset File | LMMS | Open Source |
| .XPL | Interscape | Instellingsbestanden | LcdStudio Playlist File | LCDStudio | Interscape |
| .XPX | Intercon Associates | Instellingsbestanden | Intercon FormNet File | Accessible FormNet | Intercon Associates |
| .XPY | Open Source | Instellingsbestanden | XPY Settings File | XPY | Open Source |
| .XRX | Microsoft Corporation | Instellingsbestanden | Expression Encoder Media Profile Settings | Expression Encoder | Microsoft Corporation |
| .XS | Microsoft Corporation | Instellingsbestanden | Age Of Empires 3 Map AI Generator | Microsoft Age of Empires | Ensemble Studios |
| .XST | IBM | Instellingsbestanden | WebSphere Query Template | WebSphere Application Server | IBM |
| .XTODVD | VSO Software | Instellingsbestanden | ConvertXtoDVD Project File | ConvertXtoDVD | VSO Software |
| .XTP | adnx | Instellingsbestanden | xTime Project Document | xPlan | adnx |
| .XUI | Microsoft Corporation | Instellingsbestanden | Xbox 360 User Interface File | Microsoft Visual Studio | Microsoft Corporation |
| .XVM | VMware | Instellingsbestanden | VMware Console Configuration File | VMware Workstation | VMware |
| .XWK | Intel Corporation | Instellingsbestanden | Crosstalk Communicator Keyboard Mapping | Intel Crosstalk Communicator | Intel Corporation |
| .XXS | Sorenson Media | Instellingsbestanden | Sorenson Squeeze Settings File | Squeeze | Sorenson Media |
| .YPF | David Binette | Instellingsbestanden | YahElite Personality File | YahElite | David Binette |
| .ZAP | Check Point Software Technologies Ltd. | Instellingsbestanden | ZoneAlarm Pro Data File | ZoneAlarm Antivirus | Check Point Software Technologies Ltd. |
| .ZHS | Zephyr | Instellingsbestanden | ECLIPSE Server Hotspot File | Eclipse Server | Zephyr |
| .ZON | Nuance | Instellingsbestanden | OmniPage Zone Template File | OmniPage | Nuance |
| .ZPF | AutoDesSys, Inc. | Instellingsbestanden | Form•Z Preferences File | AutoDesSys formZ | AutoDesSys, Inc. |
| .ZVT | Adobe Systems Incorporated | Instellingsbestanden | Photoshop Zoomify Preset File | Adobe Photoshop CC | Adobe Systems Incorporated |
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