| .S3D | Micrografx | Grafische Bestanden | Micrografx Simply 3D Project File | Micrografx Simply 3D | Micrografx |
| .SAF | DeLorme | Grafische Bestanden | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAIF | Safe Software | Grafische Bestanden | Spatial Archive Interchange Format | Unknown Software | Unknown Developer |
| .SAN | LucasArts Entertainment Company, LLC | Grafische Bestanden | Smush Animation File | Star Wars: Rebel Assault | LucasArts Entertainment Company, LLC |
| .SBL | Adobe Systems Incorporated | Grafische Bestanden | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SDP | Oracle Corporation | Grafische Bestanden | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SGN | Signet Bureau | Grafische Bestanden | Signet Bureau DRM File | SGN Viewer | Signet Bureau |
| .SGR | Electronic Arts | Grafische Bestanden | SimCity 4 Graphics Rules File | Electronic Arts SimCity 4 | Electronic Arts |
| .SGV | Oracle Corporation | Grafische Bestanden | StarOffice StarDraw 2.0 Picture Image File | StarOffice | Oracle Corporation |
| .SHA | Corel | Grafische Bestanden | CorelDraw Shader File | CorelDRAW Graphics Suite | Corel |
| .SHO | Show Pro Software | Grafische Bestanden | Show Pro Show Flow File | Show Pro | Show Pro Software |
| .SIA | Nevercenter | Grafische Bestanden | Silo 3D Model File | Silo | Nevercenter |
| .SLB | Autodesk, Inc. | Grafische Bestanden | AutoCAD Slide Library | Autodesk AutoCAD | Autodesk, Inc. |
| .SLDLFP | Dassault Systèmes | Grafische Bestanden | SolidWorks Library Part | Dassault Systemes SolidWorks | Dassault Systèmes |
| .SLO | Pixar | Grafische Bestanden | RenderMan Compiled File | RenderMan | Pixar |
| .SLP | Magix Software GmbH | Grafische Bestanden | SpectraLayers Pro Project | SpectraLayers Pro | Magix Software GmbH |
| .SLT | Mozilla | Grafische Bestanden | Mozilla User Profile Folder | Mozilla Firefox | Mozilla |
| .SMG | Dassault Systèmes | Grafische Bestanden | 3DVia Composer Model | 3DVIA | Dassault Systèmes |
| .SMH | Oracle Corporation | Grafische Bestanden | Sealed MHT Document | Unsealer | Oracle Corporation |
| .SMI | Apple | Grafische Bestanden | Self-Mounting Disk Image | ShrinkWrap | Aladdin Systems |
| .SMIL | "Synchronized Multimedia" Working Group (SYMM WG) | Grafische Bestanden | SMIL(Synchronized Multimedia Integration Language) Presentation File | Internet Explorer | Microsoft Corporation |
| .SNA | Tom Ehlert Software | Grafische Bestanden | Drive Snapshot Primary Backup File | Tom Ehlert Drive Snapshot | Tom Ehlert Software |
| .SST | Microsoft Corporation | Grafische Bestanden | Serialized Certificate Store File | Certificate Manager Tool | Microsoft Corporation |
| .ST6 | XnSoft | Grafische Bestanden | SBIG CCD Camera Image | XnView MP | XnSoft |
| .ST7 | XnSoft | Grafische Bestanden | SBIG CCD Camera Image | XnView MP | XnSoft |
| .ST9 | XnSoft | Grafische Bestanden | SBIG CCD Camera Image | XnView MP | XnSoft |
| .STD | Oracle Corporation | Grafische Bestanden | Apache OpenOffice Drawing Template | Apache OpenOffice | Apache Software Foundation |
| .STM | Microsoft Corporation | Grafische Bestanden | Exchange Streaming Media File | Microsoft Exchange Server | Microsoft Corporation |
| .SWL | Macromedia | Grafische Bestanden | Alternate Macromedia Flash Format | Adobe Flash Player | Adobe Systems Incorporated |
| .SXO | Modular Dreams, Inc. | Grafische Bestanden | SX Paint Saved Graphical Working Environment | SX Paint | Modular Dreams, Inc. |
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