| .S01 | Lithops Software | Gegevensbestanden | ZipSplitter Part 2 Archive | Lithops Software ZipSplitter | Lithops Software |
| .S03 | Corel Corporation | Gegevensbestanden | Corel WordPerfect Distribution File | Corel WordPerfect | Corel |
| .S2 | Motorola | Gegevensbestanden | Motorola S-record Format | Unknown Software | Unknown Developer |
| .S2P | Sonnet Software | Gegevensbestanden | Sonnet S-device Parameter Data File | Sonnet Suites | Sonnet Software |
| .S2R | Unknown Developer | Gegevensbestanden | RegMagik File | RegMagik | Unknown Developer |
| .S31 | TamoSoft | Gegevensbestanden | SmartWhois File | SmartWhois | TamoSoft |
| .S4D | RIAM (French National Network for Research and Innovation on Multimedia) | Gegevensbestanden | RIAM AVA Motion S4D Data | AVA Motion | RIAM (French National Network for Research and Innovation on Multimedia) |
| .S4MI | Motorola | Gegevensbestanden | Motorola Skin Editor Data File | Motorola Skin Editor | Motorola |
| .S4P | Open Source | Gegevensbestanden | Touchstone 16 S-parameters Data File | Notepad++ | Don Ho |
| .S4T | i4i, Inc | Gegevensbestanden | S4/TEXT And Tagless Editor Data | Unknown Software | Unknown Developer |
| .S7F | Siemens AG | Gegevensbestanden | STEP 7 Project | Step 7-Micro/WIN | Siemens AG |
| .S7S | Sony | Gegevensbestanden | Sony Ericsson S700i Phone Firmware Data | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .S8 | SIMUL8 | Gegevensbestanden | SIMUL8 Simulation Data | SIMUL8 | SIMUL8 |
| .S85 | sabre airline solutions | Gegevensbestanden | SABRE StaffPlan Chart | SABRE staffplan software | sabre airline solutions |
| .SAA | Information Security Corporation (ISC) | Gegevensbestanden | SecretAgent Encrypted Archive File | SecretAgent | Information Security Corporation (ISC) |
| .SAD | LucasArts Entertainment Company, LLC | Gegevensbestanden | Lucas Arts Sound Data | Dragon UnPACKer | Open Source |
| .SAF | DeLorme | Gegevensbestanden | Street Atlas USA Map File | DeLorme Street Atlas USA | DeLorme |
| .SAH | Berkeley Systems | Gegevensbestanden | SETI@home Data File | BOINC | University of California, Berkeley |
| .SAL | Oracle Corporation | Gegevensbestanden | SQL Application Language Source Code | MySQL | Oracle Corporation |
| .SAM | Microsoft Corporation | Gegevensbestanden | LMHOSTS Sample File | Notepad++ | Don Ho |
| .SAMPLE | Unknown Developer | Gegevensbestanden | Saved Sample | Unknown Software | Unknown Developer |
| .SAPSSD | SAP | Gegevensbestanden | SAP Data | SAP Business All-In-One | SAP |
| .SAR | Commodore International | Gegevensbestanden | Saracen Paint Image | XnView MP | XnSoft |
| .SAS7BCAT | SAS Institute Inc. | Gegevensbestanden | SAS Version 8 Random Access File Catalog | SAS | SAS Institute Inc. |
| .SAV | Nintendo | Gegevensbestanden | Saved Game File | No Cash GBA (No$GBA) | Martin Korth |
| .SAX | Open Source | Gegevensbestanden | Sedona Framework XML Application | Sedona Framework | Open Source |
| .SBA | SpeedBalance.nl | Gegevensbestanden | SpeedBalance Accounting Data | SpeedBalance | SpeedBalance.nl |
| .SBD | Microsoft Corporation | Gegevensbestanden | Office Accounting Company Data File | Microsoft Office Accounting | Microsoft Corporation |
| .SBF | Google | Gegevensbestanden | Android System File | Google Android | Google |
| .SBI | Creative Technology Ltd. | Gegevensbestanden | Sound Blaster Instrument | Virtual Sound Blaster | Creative Technology Ltd. |
| .SBK | SwishZone | Gegevensbestanden | SWiSH Project Backup File | SWiSH Max | SwishZone |
| .SBL | Adobe Systems Incorporated | Gegevensbestanden | Shockwave Flash Object | Adobe Flash Player | Adobe Systems Incorporated |
| .SBP | Autodesk, Inc. | Gegevensbestanden | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SBS | Allegorithmic | Gegevensbestanden | Substance Package | Substance Designer | Allegorithmic |
| .SBT | URUWORKS | Gegevensbestanden | SBT Subtitle File | URUWorks Subtitle Workshop | URUWORKS |
| .SBW | US Treasury | Gegevensbestanden | US Treasury Savings Bonds Wizard File | US Treasury Savings Bond Wizard | US Treasury |
| .SBX | Dream Design Entertainment Software | Gegevensbestanden | GLBasic Shoebox File | GLBasic | Dream Design Entertainment Software |
| .SC3 | EA Maxis | Gegevensbestanden | SimCity 3000 City File | Maxis SimCity 3000 | EA Maxis |
| .SCA | Symantec Corporation | Gegevensbestanden | Norton AntiVirus Scan File | Norton Antivirus | Symantec Corporation |
| .SCD | Intuit, Inc. | Gegevensbestanden | TurboTax Tax Schedule List | Intuit Quicken | Quicken |
| .SCE | Open Source | Gegevensbestanden | Scilab Script | Scilab | Open Source |
| .SCF | Microsoft Corporation | Gegevensbestanden | Windows Explorer Command | Microsoft Windows | Microsoft Corporation |
| .SCG | Midori Media | Gegevensbestanden | MyPM SCG Definition File | Midori Media myPM SCG Classic | Midori Media |
| .SCH | Autodesk, Inc. | Gegevensbestanden | EAGLE Schematics File | Autodesk EAGLE | Autodesk, Inc. |
| .SCI | Open Source | Gegevensbestanden | Scilab Script | Scilab | Open Source |
| .SCL | Avid Technology | Gegevensbestanden | Sibelius Chord Diagram Library | Avid Sibelius | Avid Technology |
| .SCM | Gimpel Software | Gegevensbestanden | GIMP Script-Fu Script | GIMP | The GIMP Development Team |
| .SCN | Microsoft Corporation | Gegevensbestanden | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCO | MR Software | Gegevensbestanden | OMSI Scenery Object Configuration File | OMSI | MR Software |
| .SCORES | Unknown Developer | Gegevensbestanden | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .SCS_TOR | Accelrys Software Inc. | Gegevensbestanden | Insight II Torsion File | Insight II | Accelrys Software Inc. |
| .SCX | RIX SoftWorks, Inc. | Gegevensbestanden | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCZ | OpenLimit SignCubes AG | Gegevensbestanden | OpenLimit SignCubes Zip Container File | OpenLimit CC Sign | OpenLimit SignCubes AG |
| .SDA | Oracle Corporation | Gegevensbestanden | StarOffice Drawing | Apache OpenOffice | Apache Software Foundation |
| .SDC | Stardock Corporation | Gegevensbestanden | Stardock Central Download Archive | Stardock Central | Stardock Corporation |
| .SDD | Programming Sunrise | Gegevensbestanden | Smart Diary Suite Data File | Smart Diary Suite | Programming Sunrise |
| .SDE | Groundlevel Software, Inc. | Gegevensbestanden | Drumbeat Exported Data File | DrumBeat | Groundlevel Software, Inc. |
| .SDF | Microsoft Corporation | Gegevensbestanden | SQL Server Compact Database File | Microsoft Visual Studio | Microsoft Corporation |
| .SDI | Intuit, Inc. | Gegevensbestanden | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDK | Autodesk, Inc. | Gegevensbestanden | AutoSketch Drawing | AutoSketch | Autodesk, Inc. |
| .SDL | Microsoft Corporation | Gegevensbestanden | Service Description Language File | Safari | Apple |
| .SDM | Oracle Corporation | Gegevensbestanden | StarOffice Mail Message | StarOffice | Oracle Corporation |
| .SDN | Robert K. Jung | Gegevensbestanden | Shareware Distributors Network File | ARJ Software JAR | Robert K. Jung |
| .SDOC | Samsung Electronics | Gegevensbestanden | Samsung Memo File | Samsung Kies | Samsung Electronics |
| .SDP | Oracle Corporation | Gegevensbestanden | StarOffice Presentation File | Apache OpenOffice | Apache Software Foundation |
| .SDS | Oracle Corporation | Gegevensbestanden | OpenOffice.org Chart | Apache OpenOffice | Apache Software Foundation |
| .SDT | Intuit, Inc. | Gegevensbestanden | QuickBooks Data File | Intuit QuickBooks Pro | Intuit, Inc. |
| .SDU | Edwards Systems Technology, Inc. | Gegevensbestanden | Edwards Systems Technology File | Unknown Software | Unknown Developer |
| .SDV | Pinnacle Systems Inc. | Gegevensbestanden | Studio DV Project File | Pinnacle Studio | Corel |
| .SDX | Kivuto | Gegevensbestanden | Kivuto Secure Download Manager File | Kivuto Secure Download Manager | Kivuto |
| .SDY | StarMoney | Gegevensbestanden | StarMoney Financial Data | StarMoney | StarMoney |
| .SEARCHCONNECTOR-MS | Microsoft Corporation | Gegevensbestanden | Microsoft Windows Search Connector Description File | Microsoft Windows | Microsoft Corporation |
| .SECURITY | Oracle Corporation | Gegevensbestanden | Javasoft Jre 1.3 Lib Security Data | Java | Oracle Corporation |
| .SEED | Open Source | Gegevensbestanden | Linux Preseed File | Ubuntu | Open Source |
| .SEG | SEG (The Society of Exploration Geophysicists) | Gegevensbestanden | SEG-2 Data File | Unknown Software | Unknown Developer |
| .SEL | Mincom | Gegevensbestanden | LinkOne Selection List File | Mincom LinkOne WebView | Mincom |
| .SEM | Alpha Software | Gegevensbestanden | Alpha Five Set Data Dictionary Memo File | Alpha Anywhere - Alpha Software | Alpha Software |
| .SEN | Neyer Software LLC | Gegevensbestanden | SenTest Data File | Neyer Software SenTest | Neyer Software LLC |
| .SEO | Link Engine Management Ltd. | Gegevensbestanden | PC Link File | PC Link | Link Engine Management Ltd. |
| .SEP | PictView software | Gegevensbestanden | Separated Image File | PictView | PictView software |
| .SEQ | PG Music Inc | Gegevensbestanden | PowerTracks Pro Audio Project File | PowerTracks Pro Audio | PG Music Inc |
| .SER | Thermo Fisher Scientific Inc. | Gegevensbestanden | GeneMapper Project File | GeneMapper | Thermo Fisher Scientific Inc. |
| .SERIAL | Apple | Gegevensbestanden | Golden Orchard Apple II CD Rom File | Apple OS X | Apple |
| .SERVER | Interscape | Gegevensbestanden | Bonobo Activation API File | GNOME Desktop | Interscape |
| .SETUP | Crytek | Gegevensbestanden | CryENGINE Character Setup File | Crytek CryENGINE SDK | Crytek |
| .SEV | Open Source | Gegevensbestanden | SevenUp Picture | ZX-Paintbrush | Open Source |
| .SF | Institut de Recherche et de Coordination Acoustique/Musique (IRCAM) | Gegevensbestanden | IRCAM Sound File | Awave Studio | FMJ-Software |
| .SF3 | Statpoint Technologies, Inc. | Gegevensbestanden | STATGRAPHICS Data File | STATGRAPHICS | Statpoint Technologies, Inc. |
| .SFA | Sony | Gegevensbestanden | Sony Sound Forge File | Sound Forge Pro | Magix Software GmbH |
| .SFF | Elecbyte | Gegevensbestanden | M.U.G.E.N. Sprite File | Elecbyte M.U.G.E.N | Elecbyte |
| .SFM | Samsung Electronics | Gegevensbestanden | S Memo Data Cache | S Memo | Samsung Electronics |
| .SFS | Open Source | Gegevensbestanden | Squashfs File Archive | 7-Zip | Igor Pavlov |
| .SG | Unknown Developer | Gegevensbestanden | SG-1000 Game ROM File | Kega Fusion | Steve Snake |
| .SGB | Relic Entertainment | Gegevensbestanden | Dawn Of War Map File | Relic Entertainment Dawn of War | Relic Entertainment |
| .SGCPO | Stenograph | Gegevensbestanden | Case CATalyst File | Case CATalyst | Stenograph |
| .SGML | Corel | Gegevensbestanden | Standard Generalized Markup Language File | Corel WordPerfect X8 | Corel |
| .SGN | Signet Bureau | Gegevensbestanden | Signet Bureau DRM File | SGN Viewer | Signet Bureau |
| .SGNGL | Stenograph | Gegevensbestanden | Case CATalyst File | Case CATalyst | Stenograph |
| .SGO | Volkswagen | Gegevensbestanden | ECU Update | Engine Control Unit (ECU) | Volkswagen |
| .SGR | Electronic Arts | Gegevensbestanden | SimCity 4 Graphics Rules File | Electronic Arts SimCity 4 | Electronic Arts |
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