| .E3 | DPT Corp | File di giochi | Think3 Thinkdesign CAD Document | ThinkDesign Suite | DPT Corp |
| .EA3 | Electronic Arts | File di giochi | FIFA 2001 Game Data | FIFA 2001 | EA Sports |
| .EAC | Emurasoft, Inc. | File di giochi | EmEditor Auto-Completion Data | EmEditor | Emurasoft, Inc. |
| .EBP | Jes-Soft | File di giochi | Jes-Soft Sports Play Description | Jes-Soft Playbook | Jes-Soft |
| .EBZ | Intersystem Concepts | File di giochi | Empire Builder Pronto Saved Game | Empire Builder Pronto | Intersystem Concepts |
| .ECL | Team Shanghai Alice | File di giochi | Touhou Stage Script | Touhou ToolKit | Touhou Patch Center |
| .ECW | ESRI (Environmental Systems Research Institute) | File di giochi | Enhanced Compression Wavelet Image | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EDT | Adobe Systems Incorporated | File di giochi | Adobe eBook Download Settings | Adobe Digital Editions | Adobe Systems Incorporated |
| .EES | Sierra Entertainment | File di giochi | Empire Earth Scenario Data | Empire Earth | Sierra Entertainment |
| .EFF | The Hotline Group | File di giochi | eFileFolders File Format | eFileFolders | The Hotline Group |
| .EFT | Cay Horstmann | File di giochi | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EFX | j2 Global, Inc. | File di giochi | eFax Document | j2 Global Communications eFax | j2 Global, Inc. |
| .EGM | Pangea Software, Inc. | File di giochi | Pangea Enigmo Custom Game Data | Pangea Software Enigmo | Pangea Software, Inc. |
| .EGT | EagleGet | File di giochi | EagleGet Temporary File | EagleGet | EagleGet |
| .EIC | Nitro Games | File di giochi | East Indian Company Save Game File | East India Company | Nitro Games |
| .EK6 | Open Source | File di giochi | Generation 6 Pokémon Save File | PKHeX | Open Source |
| .EKV | Valve | File di giochi | Left 4 Dead Game Data | Left 4 Dead | Valve |
| .EKX | Open Source | File di giochi | Encrypted 3DS Pokémon Save File | PKHeX | Open Source |
| .ELF | Nintendo | File di giochi | Nintendo Wii Game File | Dolphin (emulator) | Dolphin Emulator Project |
| .ELM | Open Source | File di giochi | Eternal Lands Map File | Eternal Lands | Open Source |
| .EMI | Blitwise Productions | File di giochi | Pocket Tanks Emitter File | Pocket Tanks | Blitwise Productions |
| .EMM | MindMaple Inc. | File di giochi | MindMaple Map | MindMaple | MindMaple Inc. |
| .ENC | Smith Micro Software | File di giochi | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | File di giochi | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENG | Unknown Developer | File di giochi | Chess Engine | ChessMaster | Ubisoft Blue Byte |
| .ENV | Adobe Systems Incorporated | File di giochi | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .EPC | Sumo Digital Ltd. | File di giochi | Doctor Who Game Data File | BBC Doctor Who: The Adventure Games | Sumo Digital Ltd. |
| .EPK | LG Electronics | File di giochi | LG Firmware Package | epk2extract | openlgtv |
| .ERB | Open Source | File di giochi | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ERF | BioWare | File di giochi | BioWare Entity Resource File | BioWare Neverwinter Nights | BioWare |
| .ERP | Future Games | File di giochi | Alter Ego Game Archive | Alter Ego | Future Games |
| .ES | Interscape | File di giochi | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESG | Pangea Software, Inc. | File di giochi | Enigmo Saved Game File | Pangea Software Enigmo | Pangea Software, Inc. |
| .ESI | Open Source | File di giochi | Escape Level Index File | Escape | Open Source |
| .ESM | Bethesda Softworks | File di giochi | Bethesda Softworks Master File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESN | Epic Games | File di giochi | Unreal Engine Language Localization | Unreal Tournament | Epic Games |
| .ESP | Bethesda Softworks | File di giochi | Elder Scrolls Plugin File | Bethesda Softworks TES Construction Set | Bethesda Softworks |
| .ESS | Bethesda Softworks | File di giochi | The Elder Scrolls Saved Game | Skyrim VR | Bethesda Softworks |
| .ESX | Xactware Solutions | File di giochi | Xactimate Insurance Claims Estimate | Xactimate | Xactware Solutions |
| .EU4 | Paradox Development Studio | File di giochi | Europa Universalis IV Saved Game | Europa Universalis IV | Paradox |
| .EUR | Capcom | File di giochi | Monster Hunter Freedom Unite EU Region Saved Game | Monster Hunter Freedom Unite | Capcom |
| .EVP | Miracle Castle | File di giochi | Talisman Online Game Data | Talisman Online | Miracle Castle |
| .EWL | Green Eclipse | File di giochi | EclipseCrossword Word List File | Green Eclipse EclipseCrossword | Green Eclipse |
| .EXC | Lionhead Studios | File di giochi | Black & White Zone File | Lionhead Studios Black and White | Lionhead Studios |
| .EXL | SysTools Solutions | File di giochi | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXS | Apple | File di giochi | EXS Instrument | Apple Logic Pro | Apple |
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