| .SAI | SYSTEMAX Software Development | Fichiers Raster Image | PaintTool SAI Image | PaintTool SAI | SYSTEMAX Software Development |
| .SAI2 | SYSTEMAX Software Development | Fichiers Raster Image | Paint Tool SAI Version 2 Drawing | PaintTool SAI | SYSTEMAX Software Development |
| .SAR | Commodore International | Fichiers Raster Image | Saracen Paint Image | XnView MP | XnSoft |
| .SBP | Autodesk, Inc. | Fichiers Raster Image | Sketchbook Express iCloud Image | SketchBook | Autodesk, Inc. |
| .SCANNER | Unknown Developer | Fichiers Raster Image | Scanner Output File | Unknown Software | Unknown Developer |
| .SCG | Midori Media | Fichiers Raster Image | MyPM SCG Definition File | Midori Media myPM SCG Classic | Midori Media |
| .SCN | Microsoft Corporation | Fichiers Raster Image | Age Of Mythology Scenario File | Microsoft Age of Empires | Ensemble Studios |
| .SCP | RIX SoftWorks, Inc. | Fichiers Raster Image | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCT | Scitex | Fichiers Raster Image | Scitex Continuous Tone File | Adobe Photoshop | Adobe Systems Incorporated |
| .SCU | RIX SoftWorks, Inc. | Fichiers Raster Image | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SCX | RIX SoftWorks, Inc. | Fichiers Raster Image | ColoRIX Bitmap Graphic File | XnView MP | XnSoft |
| .SDG | Golden Software LLC | Fichiers Raster Image | Strater Project File | Strater | Golden Software LLC |
| .SDR | Dell Boomi | Fichiers Raster Image | Dell Support File | Unknown Software | Unknown Developer |
| .SEP | PictView software | Fichiers Raster Image | Separated Image File | PictView | PictView software |
| .SFC | Unknown Developer | Fichiers Raster Image | Super Nintendo ROM | Snes9x | Snes9x Team |
| .SFF | Elecbyte | Fichiers Raster Image | M.U.G.E.N. Sprite File | Elecbyte M.U.G.E.N | Elecbyte |
| .SFW | Seattle Lab | Fichiers Raster Image | Seattle FilmWorks Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SGD | Syngene | Fichiers Raster Image | GeneSnap Image File | GeneSnap | Syngene |
| .SGI | Silicon Graphics, Inc. | Fichiers Raster Image | Silicon Graphics Image File | Canvas X | ACD Systems |
| .SHG | Microsoft Corporation | Fichiers Raster Image | Segmented Hyper-Graphic | Microsoft WinHelp | Microsoft Corporation |
| .SID | Valve | Fichiers Raster Image | Steam Game Data Backup File | Steam | Valve |
| .SIG | Unknown Developer | Fichiers Raster Image | Signature File | Microsoft Outlook Express | Microsoft Corporation |
| .SIM | Valve | Fichiers Raster Image | Steam Game Backup Information File | Steam | Valve |
| .SIX | Digital Equipment Corporation | Fichiers Raster Image | DEC LN03+ Sixel Bitmap Image File | Unknown Software | Unknown Developer |
| .SKM | Trimble Inc. | Fichiers Raster Image | SketchUp Materials File | SketchUp | Trimble Inc. |
| .SLD | ESRI (Environmental Systems Research Institute) | Fichiers Raster Image | Styled Layer Descriptor | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .SMP | MakeMusic, Inc. | Fichiers Raster Image | SmartMusic Performance File | SmartMusic | MakeMusic, Inc. |
| .SNAP | Erik Kunze | Fichiers Raster Image | ZX Spectrum Emulator Mirage Microdrive Snapshot | XZX-Pro | Erik Kunze |
| .SOB | Apache Software Foundation | Fichiers Raster Image | OpenOffice.org Impress Bimap Styles File | Apache OpenOffice | Apache Software Foundation |
| .SPA | Yu Higuchi | Fichiers Raster Image | MikuMikuDance Sphere Mapping File | MikuMikuDance | Yu Higuchi |
| .SPC | Various Developers | Fichiers Raster Image | Software Publisher Certificate File | OpenSSL | Open Source |
| .SPE | IBM | Fichiers Raster Image | SPSS Extension | IBM SPSS | IBM |
| .SPH | National Institute of Standards and Technology (NIST) | Fichiers Raster Image | NIST SPHERE Audio File | SoX | Open Source |
| .SPIFF | Joint Photographic Experts Group | Fichiers Raster Image | Still Picture Interchange File Format | Unknown Software | Unknown Developer |
| .SPJ | IBM | Fichiers Raster Image | SPSS Production Job File | IBM SPSS | IBM |
| .SPOT | SPOT Image | Fichiers Raster Image | SPOT Satellite Image | SPOT Images | SPOT Image |
| .SPP | Serif | Fichiers Raster Image | Serif PhotoPlus Picture File | PhotoPlus | Serif |
| .SPR | Valve | Fichiers Raster Image | Half-Life Sprite File | Half-Life | Valve |
| .SPRITE | MIT Media Lab | Fichiers Raster Image | Scratch Sprite File | MIT Scratch | MIT Media Lab |
| .SPS | IBM | Fichiers Raster Image | SPSS Program File | IBM SPSS | IBM |
| .SPU | Atari Corporation | Fichiers Raster Image | Spectrum 512 Image | Lemkesoft GraphicConverter | Lemkesoft |
| .SR | Sun Microsystems | Fichiers Raster Image | Sun Raster Image File | GIMP | The GIMP Development Team |
| .SRS | Microsoft Corporation | Fichiers Raster Image | Outlook Send/Receive Settings File | Microsoft Outlook | Microsoft Corporation |
| .SSI | Adobe Systems Incorporated | Fichiers Raster Image | Adobe Dreamweaver Server Side Include File | Adobe Dreamweaver | Adobe Systems Incorporated |
| .STG | Microsoft Corporation | Fichiers Raster Image | ActiveSync Backup File | Microsoft ActiveSync | Microsoft Corporation |
| .SUL | Unknown Developer | Fichiers Raster Image | GFA Raytrace Image | GFA Raytrace | Unknown Developer |
| .SUN | Sun Microsystems | Fichiers Raster Image | Sun Raster Graphic File | GIMP | The GIMP Development Team |
| .SUNIFF | Sun Microsystems | Fichiers Raster Image | Sun TAAC Image | XnView MP | XnSoft |
| .SUP | Unknown Developer | Fichiers Raster Image | Subtitle Bitmap File | IfoEdit | Open Source |
| .SVA | Viz Media | Fichiers Raster Image | Manga Browser Comic File | Sharp Manga Browser for SHONEN JUMP | Viz Media |
| .SVM | Star Division | Fichiers Raster Image | StarView Metafile | Apache OpenOffice | Apache Software Foundation |
| .SVS | Nintendo | Fichiers Raster Image | Game Boy Advance Saved State File | Game Boy Advance | Nintendo |
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