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| Extension | File Type Developer | File Category | File Type Description | Primary Software | Primary Software Developer |
|---|---|---|---|---|---|
| .U2C | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .U2E | Unreal Software | Uncommon Files | Unreal Game Translation | Unknown Software | Unknown Developer |
| .UAD | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .UBM | Apple | Uncommon Files | IPhoto Mtwain Install File | Apple iPhoto | Apple |
| .UBS | Microsoft Corporation | Uncommon Files | Tracesrv Bugslayer Utility File | Tracesrv Bugslayer Windows Utility Software | Microsoft Corporation |
| .UCA | Unknown Developer | Uncommon Files | Unicode Collation Algorithm Data File | Unknown Software | Unknown Developer |
| .UDI | Pinnacle Systems Inc. | Uncommon Files | Dazzle DVD Complete File | Dazzle DVD Complete | Pinnacle Systems Inc. |
| .UHS | Jason Strautman | Uncommon Files | Universal Hint System Binary Data File | Universal Hint System | Jason Strautman |
| .UK_ | Unknown Developer | Uncommon Files | Mcguiness File | Unknown Software | Unknown Developer |
| .UNIX BAR COMPRESSED FILE ARCHIVE | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .UNKNOWN | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .UNL | Garmin | Uncommon Files | Garmin Unlock File | MapSource | Garmin |
| .UNM | Unknown Developer | Uncommon Files | Uncommon File Extension | Unknown Software | Unknown Developer |
| .UP2 | Ulead Systems | Uncommon Files | Ulead Cool 3D Plugins Board File | MotionStudio 3D | Corel |
| .UPDATED | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .UPG | Unknown Developer | Uncommon Files | Upgrade File | ANCILE uPerform Client | ANCILE Solutions |
| .USAGE | Unknown Developer | Uncommon Files | Unknown Apple II File. (found On Golden Orchard Apple II CD Rom) | Atom | GitHub, Inc. |
| .USB | SiSoftware | Uncommon Files | SiSoftware Sandra Data | SiSoftware Sandra | SiSoftware |
| .UVC | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .UXR | Unknown Developer | Uncommon Files | Unknown File Type | Unknown Software | Unknown Developer |
| .UXT | WaveMetrics | Uncommon Files | IGOR Pro Unpacked Experiment Template File | IGOR Pro | WaveMetrics |
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