| .EAP | Sparx Systems | Settings Files | Enterprise Architect Project | Enterprise Architect | Sparx Systems |
| .ECELP4800 | Nuera Communications | Settings Files | Nuera ECELP Speech Codec Family | Unknown Software | Unknown Developer |
| .ECF | Microsoft Corporation | Settings Files | Outlook Add-in | Microsoft Outlook | Microsoft Corporation |
| .ECU | Open Source | Settings Files | TunerPro ECU Configurator Data | TunerPro | Open Source |
| .EDL | Avid Technology | Settings Files | Edit Decision List File | Adobe Premiere Pro CC | Adobe Systems Incorporated |
| .EDR | BALARAD | Settings Files | Embird Color Palette | Embroidermodder 2 | Open Source |
| .EFC | Unknown Developer | Settings Files | EFCoins File | Unknown Software | Unknown Developer |
| .EFT | Cay Horstmann | Settings Files | ChiWriter High Resolution Screen Font | ChiWriter | Cay Horstmann |
| .EHI | Evozi | Settings Files | HTTP Injector Config File | HTTP Injector | Evozi |
| .ELE | Zemax | Settings Files | ZEMAX Element Drawing Settings | ZEMAX | Zemax |
| .ELM | Open Source | Settings Files | Eternal Lands Map File | Eternal Lands | Open Source |
| .EMM | MindMaple Inc. | Settings Files | MindMaple Map | MindMaple | MindMaple Inc. |
| .ENC | Smith Micro Software | Settings Files | Encoded Data File | Smith Micro StuffIt Deluxe | Smith Micro Software |
| .END | Corel | Settings Files | CorelDRAW Arrow-head Definition Data | CorelDRAW Graphics Suite | Corel |
| .ENP | Thomson Reuters Corporation | Settings Files | EndNote Preferences File | EndNote | Thomson Reuters Corporation |
| .ENS | Thomson Reuters Corporation | Settings Files | EndNote Style File | EndNote | Thomson Reuters Corporation |
| .ENV | Adobe Systems Incorporated | Settings Files | Adobe Dictionary Data File | Adobe Illustrator CC | Adobe Systems Incorporated |
| .ENZ | Thomson Reuters Corporation | Settings Files | EndNote Connection File | Thomson Reuters EndNote | Clarivate Analytics |
| .EPR | Adobe Systems Incorporated | Settings Files | Photoshop AME Preset File | Adobe Photoshop CC | Adobe Systems Incorporated |
| .EPRO | Open Source | Settings Files | eProxy For Android Configuration File | eProxy for Android | Open Source |
| .EQF | Nullsoft | Settings Files | Winamp Equalizer Preset File | Nullsoft Winamp | Nullsoft |
| .EQL | Design Science | Settings Files | MathType Settings | Design Science MathType | Design Science |
| .EQP | Design Science | Settings Files | MathType Preferences | MathType | Design Science |
| .ESI | Open Source | Settings Files | Escape Level Index File | Escape | Open Source |
| .ETFF | Encrypt4all Software | Settings Files | Encrypt4all Theme File | Encrypt4all | Encrypt4all Software |
| .EUM | WaveRider Communications Inc. | Settings Files | Enterprise User Monitor Configuration File | WaveRider EUM Configuration Utility | WaveRider Communications Inc. |
| .EV3 | The LEGO Group | Settings Files | LEGO MINDSTORMS EV3 Project | LEGO MINDSTORMS EV3 | The LEGO Group |
| .EVP | Miracle Castle | Settings Files | Talisman Online Game Data | Talisman Online | Miracle Castle |
| .EWPRJ | National Instruments | Settings Files | Ultiboard Layout Project | Circuit Design Suite | National Instruments |
| .EX | Symantec Corporation | Settings Files | Norton Ghost Template Data | Symantec Ghost Solution Suite | Symantec Corporation |
| .EXA | Aquila Software | Settings Files | Examine32 Saved Search Paramaters File | Examine32 | Aquila Software |
| .EXAMPLE | Open Source | Settings Files | Example Configuration File | Notepad++ | Don Ho |
| .EXP | Unknown Developer | Settings Files | Symbols Export File | Microsoft Visual Studio | Microsoft Corporation |
| .EXT | Symantec Corporation | Settings Files | Norton Commander Extension | Norton Commander | Symantec Corporation |
| .EZHEX | Logitech | Settings Files | Logitech Harmony Configuration File | Harmony Advanced Universal Remote | Logitech |
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