| .EAR | Oracle Corporation | Audio Files | Java Enterprise Archive File | WebSphere Application Server | IBM |
| .EC3 | Epson US | Audio Files | EPSON Print CD File | EPSON Print CD | Epson US |
| .ECELP7470 | Nuera Communications | Audio Files | Nuera Audio File | Unknown Software | Unknown Developer |
| .EFA | Chicken Systems | Audio Files | Ensoniq ASR File | Chicken Systems Translator | Chicken Systems |
| .EFE | E-mu Systems | Audio Files | Ensoniq EPS File | Chicken Systems Ensoniq Disk Tools | Chicken Systems |
| .EFK | FMJ-Software | Audio Files | Ensoniq KT Instrument File | Awave Studio | FMJ-Software |
| .EFQ | Chicken Systems | Audio Files | Ensoniq SQ1/SQ2/KS-32 File | Chicken Systems Translator | Chicken Systems |
| .EFS | ESRI | Audio Files | ESRI Spatial Binary File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .EFV | Chicken Systems | Audio Files | Ensoniq VFX-SD File | Chicken Systems Translator | Chicken Systems |
| .ELIST | Diekollegen.at | Audio Files | Emperor Media Player Playlist File | Emperor Media Player | Diekollegen.at |
| .EMB | Everest Software | Audio Files | Everest Embedded Bank File | Awave Studio | FMJ-Software |
| .EMD | FMJ-Software | Audio Files | ABT Extended Module File | Awave Studio | FMJ-Software |
| .EMP | Open Source | Audio Files | eMusic Music Download File | eMusic/J | Open Source |
| .EMX | Open Source | Audio Files | eMusic Download File | eMusic/J | Open Source |
| .EMY | Sony | Audio Files | eMelody Ringtone File | Sony Ericsson Mobile Phones | Sony Mobile Communications |
| .ENF | Thomson Reuters Corporation | Audio Files | EndNote Filter File | EndNote | Thomson Reuters Corporation |
| .ENS | Thomson Reuters Corporation | Audio Files | EndNote Style File | EndNote | Thomson Reuters Corporation |
| .EOP | Everyone Piano Inc. | Audio Files | EveryonePiano Music Score File | Everyone Piano | Everyone Piano Inc. |
| .EOV | Epson US | Audio Files | Epson Voice Creation Tool Voice Data | Voice Creation Tool | Epson US |
| .EPM | THE BAKED BEAN COMPANY | Audio Files | Electric Pipes Music | Electric Pipes | THE BAKED BEAN COMPANY |
| .EPT | Adobe Systems Incorporated | Audio Files | Adobe Encapsulated PostScript Interchange Format With TIFF Preview | Adobe Acrobat DC | Adobe Systems Incorporated |
| .ERB | Open Source | Audio Files | Ruby ERB Script | Microsoft Notepad | Microsoft Corporation |
| .ES | Interscape | Audio Files | ECHOSPEECH File | ECHOSPEECH | Interscape |
| .ESPS | Various Developers | Audio Files | ESPS Sampled Data File | The Hidden Markov Model Toolkit (HTK) | Machine Intelligence Laboratory |
| .ESU | Electronic Solutions Ulm | Audio Files | LokSound Electronic Sound File | LokSound | Electronic Solutions Ulm |
| .ETA | Google | Audio Files | Google Earth Placemark File | ESRI ArcGIS for Desktop | ESRI (Environmental Systems Research Institute) |
| .ETM | Etreppid Technologies, LLC | Audio Files | eTreppid Audio File | Unknown Software | Unknown Developer |
| .ETV | Open Source | Audio Files | eTreppid Audio Data | eTplayer | Open Source |
| .ETW | Enter Tech | Audio Files | Enter Tech Recorded Audio | Unknown Software | Unknown Developer |
| .EUPH | Nokia | Audio Files | Nokia File | Nokia phones | Nokia |
| .EVO | eZuce SRN | Audio Files | SeeVogh Player Video Recording | SeeVogh Player | eZuce SRN |
| .EVR | Qualcomm | Audio Files | Enhanced Variable Rate Audio File | RealPlayer | Realtime Technologies |
| .EXB | CAXA | Audio Files | CAXA Draft | IronCAD | IronCAD, LLC |
| .EXL | SysTools Solutions | Audio Files | Export Lister File | SysTools Export Notes | SysTools Solutions |
| .EXS | Apple | Audio Files | EXS Instrument | Apple Logic Pro | Apple |
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